Table 3.

Analysis of 20 leptin-melanocortin-neurotrophin system gene SNPs and BMI (in kg/m²) in AN

Gene	SNP	Genotype	M ± SD			p
Gene	SNP	Genotype	curBMI	minBMI	maxBMI	curBMI	minBMI	maxBMI
LEPR	rs1137100	G/G	17.96 ± 2.63	14.29 + 2.02	20.96 ± 2.69
		G/A	18.13 ± 2.62	13.72 + 1.99	21.04 ± 2.41	0.6923	0.9333	0.1834
		A/A	18.00 ± 2.78	13.85 + 1.91	21.10 ± 2.41

LEPR	rs1137101	G/G	17.76 ± 2.40	14.05 + 1.92	20.70 ± 2.40
		G/A	18.15 ± 2.77	13.62 + 1.96	21.17 ± 2.45	0.2348	0.6239	0.0428
		A/A	18.05 ± 2.80	13.97 + 1.93	21.13 ± 2.39

POMC	rs1042571	A/A	17.59 ± 2.84	13.89 + 2.09	21.36 ± 2.30
		A/G	18.19 ± 2.72	13.86 + 1.84	21.07 ± 2.48	0.8043	0.5856	0.8258
		G/G	17.94 ± 2.74	13.75 + 1.99	21.05 ± 2.45

GHRL	rs4684677^a	A/A	18.73 ± 2.12	14.62 + 1.11	21.59 ± 1.74
		A/T	17.99 ± 2.80	13.85 + 1.84	20.95 ± 2.24	0.9765	0.5865	0.8682
		T/T	18.04 ± 2.72	13.79 + 1.97	21.07 ± 2.44

GHRL	rs696217	T/T	17.74 ± 1.88	13.87 + 2.35	21.67 ± 2.43
		T/G	18.48 ± 2.70	14.07 + 2.07	21.46 ± 2.74	0.08005	0.0786	0.0878
		G/G	17.99 ± 2.72	13.78 + 1.93	21.00 ± 2.36

HRHl	rs12490160	G/G	18.42 ± 2.62	13.63 + 1.61	20.75 ± 2.13
		G/T	17.86 ± 2.82	13.84 + 1.81	20.96 ± 2.48	0.7484	0.7707	0.9613
		T/T	18.09 ± 2.70	13.82 + 1.99	21.11 ± 2.41

HRHl	rs3732941	G/G	18.31 ± 1.62	14.12 + 2.06	21.11 ± 1.75
		G/A	17.71 ± 2.86	13.92 + 1.87	20.94 ± 2.66	0.04668	0.5845	0.4187
		A/A	18.15 ± 2.67	13.79 + 1.97	21.11 ± 2.36

LEP	rs7799039	A/A	18.23 ± 3.02	13.59 + 2.06	21.33 ± 2.58
		A/G	18.01 ± 2.67	13.88 + 1.84	20.96 ± 2.42	0.4991	0.1125	0.3648
		G/G	17.98 ± 2.54	13.88 + 2.05	21.06 ± 2.29

NTRK2	rs1187325	C/C	18.07 ± 2.81	13.71 + 1.93	21.21 ± 2.66
		C/G	18.01 ± 2.73	13.83 + 1.97	21.11 ± 2.43	0.7365	0.5963	0.1161
		G/G	18.07 ± 2.67	13.81 + 1.94	20.85 ± 2.23

NTRK2	rs1078947	T/T	17.19 ± 2.65	13.92 + 1.86	20.37 ± 2.73
		T/C	18.02 ± 2.72	13.81 + 2.01	21.14 ± 2.42	0.1640	0.4541	0.1993
		C/C	18.12 ± 2.72	13.84 + 1.93	21.08 ± 2.41

BDNF	rs6265	T/T	17.95 ± 2.01	14.49 + 1.37	21.05 ± 1.95
		T/C	18.07 ± 2.72	13.74 + 2.02	20.96 ± 2.41	0.8167	0.3437	0.5954
		C/C	18.04 ± 2.75	13.82 + 1.94	21.12 ± 2.45

BDNF	rs56164415^a	T/T	19.69 ± 1.78	14.29 + 2.80	20.77 ± 1.47
		T/C	17.42 ± 2.68	13.54 + 2.05	21.06 ± 2.28	0.1083	0.3602	0.8950
		C/C	18.10 ± 2.70	13.85 + 1.94	21.07 ± 2.44

NTRK3	rs7180942	C/C	17.96 ± 2.63	14.29 + 2.02	21.12 ± 2.43
		C/T	18.13 ± 2.62	13.72 + 1.99	21.16 ± 2.45	0.6923	0.9333	0.3030
		T/T	18.00 ± 2.78	13.85 + 1.91	20.86 ± 2.38

AGRP	rs5030980^a	T/T	18.38 ± 2.70	10.76 + 0.00	23.94 ± 0.00
		T/G	18.05 ± 2.71	14.23 + 1.86	21.28 ± 2.37	0.0174	0.1066	0.6527
		G/G	17.74 ± 2.72	13.79 + 1.96	21.06 ± 2.43

AGRP	rs13338499	G/G	14.79 ± 0.00	14.89 + 2.33	21.66 ± 2.22
		G/A	18.26 ± 2.76	14.32 + 1.86	21.20 ± 2.21	0.7789	0.0013	0.8917
		A/A	18.05 ± 2.70	13.70 + 1.95	21.03 ± 2.46

MC4R	rs17782313	C/C	19.17 ± 2.51	13.88 + 2.15	21.43 ± 2.69
		C/T	18.12 ± 2.55	13.89 + 1.79	21.15 ± 2.46	0.6449	0.2203	0.0776
		T/T	18.03 ± 2.73	13.77 + 2.02	20.99 ± 2.36

MC4R	rs489693	A/A	18.08 ± 2.79	13.87 + 1.99	21.39 ± 2.82
		A/C	18.27 ± 2.75	13.85 + 1.82	21.12 ± 2.41	0.1252	0.5680	0.0892
		C/C	17.92 ± 2.68	13.79 + 2.04	20.98 ± 2.36

MC4R	rs8087522	A/A	18.19 ± 2.83	13.91 + 1.97	21.04 ± 2.26
		A/G	18.14 ± 2.73	13.88 + 1.85	20.94 ± 2.46	0.2651	0.0638	0.3360
		G/G	17.96 ± 2.68	13.75 + 2.04	21.18 ± 2.42

MC3R	rs6127698	T/T	17.37 ± 2.86	13.76 + 1.99	20.98 ± 2.46
		T/G	18.11 ± 2.67	13.91 + 1.89	20.96 ± 2.38	0.2276	0.6160	0.3055
		G/G	18.13 ± 2.71	13.70 + 2.02	21.34 ± 2.46

MC3R	rs3827103	G/G	17.80 ± 2.63	11.69 + 1.27	20.58 ± 2.66
		G/A	18.16 ± 2.69	13.87 + 1.88	21.63 ± 2.59	0.2974	0.1466	0.3058
		A/A	18.04 ± 2.82	13.83 + 1.96	20.99 ± 2.39

Note 1: Age, age of onset, and AN subtype entered as covariates in log additive linear regression models.

Note 2: Corrected alpha set at 0.0027 for statistical significance. Results in bold represent statistical significance.

MAF<0.07