Table 4.

Analysis of 20 leptin-melanocortin-neurotrophin system gene SNPs and BMI (in kg/m²) in BN

Gene	SNP	Genotype	M ± SD			p
Gene	SNP	Genotype	curBMI	minBMI	maxBMI	curBMI	minBMI	maxBMI
LEPR	rs1137100	G/G	21.43 ± 8.23	20.39 ± 1.58	25.45 ± 2.29
		G/A	22.82 ± 5.55	20.21 ± 1.48	26.18 ± 3.05	0.5740	0.2701	0.6248
		A/A	22.9 ± 4.15	19.97 ± 1.59	25.62 ± 3.14

LEPR	rs1137101	G/G	22.73 ± 5.96	20.37 ± 1.45	25.58 ± 2.90
		G/A	22.85 ± 4.91	20.03 ± 1.58	25.80 ± 3.05	0.9011	0.2830	0.8491
		A/A	22.43 ± 4.91	19.96 ± 1.42	25.85 ± 3.10

POMC	rs1042571	A/A	24.49 ± 3.76	19.91 ± 1.16	26.92 ± 3.50
		A/G	23.72 ± 3.28	20.18 ± 1.37	26.39 ± 3.26	0.04465	0.6690	0.0159
		G/G	22.36 ± 5.34	20.11 ± 1.64	25.51 ± 2.94

GHRL	rs4684677^a	A/A	23.30 ± 1.55	19.09 ± 0.38	24.62 ± 0.33
		A/T	23.38 ± 2.41	20.20 ± 1.47	26.07 ± 2.54	0.5120	0.9918	0.7216
		T/T	22.67 ± 5.31	20.08 ± 1.56	25.78 ± 3.12

GHRL	rs696217	T/T	23.04 ± 3.37	20.11 ± 1.59	28.66 ± 2.37
		T/G	23.09 ± 3.17	20.02 ± 1.50	25.46 ± 3.18	0.9337	0.7947	0.8488
		G/G	22.69 ± 5.36	20.10 ± 1.56	25.83 ± 3.03

HRHl	rs12490160	G/G	19.85 ± 2.36	17.99 ± 2.54	22.85 ± 1.77
		G/T	22.61 ± 5.81	19.83 ± 1.35	25.56 ± 3.39	0.3885	0.0647	0.2264
		T/T	22.82 ± 4.91	20.17 ± 1.57	25.91 ± 2.98

HRHl	rs3732941	G/G	25.21 ± 3.25	20.19 ± 1.54	27.29 ± 3.34
		G/A	22.84 ± 2.70	20.19 ± 1.44	25.72 ± 2.89	0.5918	0.6139	0.6820
		A/A	22.64 ± 5.62	20.06 ± 1.59	25.80 ± 3.11

LEP	rs7799039	A/A	23.4 ± 3.56	20.18 ± 1.69	25.73 ± 3.19
		A/G	22.76 ± 6.03	20.26 ± 1.65	25.95 ± 3.10	0.1018	0.0797	0.4461
		G/G	22.34 ± 4.24	19.77 ± 1.20	25.69 ± 2.93

NTRK2	rs1187325	C/C	22.74 ± 3.48	19.95 ± 1.87	25.29 ± 3.12
		C/G	22.18 ± 6.68	20.17 ± 1.49	25.83 ± 3.03	0.2841	0.4879	0.1866
		G/G	23.40 ± 2.94	20.15 ± 1.48	26.06 ± 3.04

*NTRK2*	rs1078947	T/T	25.70 ± 3.86	20.74 ± 2.16	27.68 ± 2.88
		T/C	23.44 ± 5.22	20.47 ± 1.78	26.63 ± 3.37	0.0773	0.0113	0.0018
		C/C	22.36 ± 5.07	19.97 ± 1.44	25.47 ± 2.90

BDNF	rs6265	T/T	22.09 ± 3.55	19.86 ± 1.04	23.99 ± 2.54
		T/C	23.03 ± 2.71	19.85 ± 1.37	25.56 ± 2.97	0.7843	0.1104	0.2622
		C/C	22.64 ± 5.89	20.21 ± 1.62	25.98 ± 3.10

BDNF	rs56164415^a	T/T	20.20 ± 0.00	20.20 ± 0.00	24.27 ± 0.00
		T/C	23.19 ± 2.60	20.19 ± 1.46	25.42 ± 2.89	0.9172	0.8701	0.3244
		C/C	22.72 ± 5.27	20.08 ± 1.56	25.87 ± 3.08

NTRK3	rs7180942	C/C	23.04 ± 2.89	20.08 ± 1.41	25.51 ± 3.25
		C/T	22.07 ± 6.48	19.87 ± 1.38	25.45 ± 2.29	0.5053	0.2122	0.6312
		T/T	23.62 ± 3.15	20.42 ± 1.78	26.18 ± 3.05

AGRP	rs5030980^a	T/T	-	-	-
		T/G	22.76 ± 8.33	20.34 ± 1.40	26.36 ± 3.53	0.8713	0.6000	0.7875
		G/G	22.76 ± 4.70	20.07 ± 1.56	25.78 ± 3.02

AGRP	rs13338499	G/G	22.11 ± 1.53	19.65 ± 0.66	25.18 ± 0.59
		G/A	23.30 ± 6.53	20.32 ± 1.51	26.35 ± 3.17	0.6047	0.6250	0.5617
		A/A	22.64 ± 4.99	20.06 ± 1.57	25.76 ± 3.08

MC4R	rs17782313	C/C	20.87 ± 8.52	20.10 ± 1.46	25.32 ± 2.73
		C/T	22.65 ± 4.49	19.85 ± 1.44	25.78 ± 3.26	0.5535	0.1953	0.2916
		T/T	23.01 ± 4.95	20.24 ± 1.60	25.90 ± 2.99

MC4R	rs489693	A/A	21.01 ± 6.55	19.59 ± 1.12	24.57 ± 2.42
		A/C	22.81 ± 4.06	20.01 ± 1.49	25.85 ± 3.04	0.2942	0.0318	0.0165
		C/C	23.11 ± 5.57	20.29 ± 1.66	26.09 ± 3.16

MC4R	rs8087522	A/A	23.64 ± 2.64	20.19 ± 1.44	26.14 ± 3.35
		A/G	22.22 ± 6.10	20.01 ± 1.44	25.87 ± 3.03	0.9886	0.8120	0.5316
		G/G	23.05 ± 4.36	20.14 ± 1.65	25.74 ± 3.06

MC3R	rs6127698	T/T	22.72 ± 5.60	20.12 ± 1.59	26.19 ± 3.52
		T/G	23.11 ± 4.34	20.17 ± 1.63	25.78 ± 2.97	0.2830	0.5759	0.2403
		G/G	22.23 ± 5.77	19.95 ± 1.39	25.65 ± 2.91

MC3R	rs3827103	G/G	23.91 ± 4.49	20.13 ± 1.70	27.93 ± 3.46
		G/A	22.60 ± 5.97	20.02 ± 1.47	26.08 ± 3.48	0.6214	0.8925	0.5723
		A/A	22.78 ± 4.91	20.10 ± 1.56	25.75 ± 2.97

Note 1: Age, age of onset, and source entered as covariates in log additive linear regression models.

Note 2: Corrected alpha set at 0.0027 for statistical significance. Results in bold represent statistical significance.

MAF<0.07