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. 2014 Oct 9;8(10):e3192. doi: 10.1371/journal.pntd.0003192

Table 3. Knowledge of early signs of shock and warning signs for severe dengue, how to make laboratory diagnosis and reported criteria for referral to hospital.* .

Overall (n = 708)Group 1 (n = 138)Group 2 (n = 282)Group 3 (n = 288) p-value
No./Total No. Who Answered: Estimated Percentage (95% CI)
Clinical diagnosis (% who always use):
Use 1997 WHO case definition 624/678: 92(90,94) 15/128: 88(80,93) 255/273: 93(90,96) 254/277: 92(88,94) 0.20
Use platelet count 654/685: 96(94,97) 122/130: 95(90,97) 265/278: 95(92,97) 267/277: 96(94,98) 0.66
Use white cell count 600/680: 89(86,91) 111/130: 86(80,91) 245/275: 89(85,92) 244/275: 89(84,92) 0.76
Use tourniquet test 119/626: 19(16,22) 19/126: 11(8,16) 48/253: 19(5,24) 52/247: 21(17,26) 0.07
Knowledge (% who correctly identified):
Tachycardia & delayed capillary refill as early sign of shock 215/708: 29(26,33) 54/138: 38(30,46) 101/282: 36(31,41) 60/288: 21(17,26) <0.001
Severe abdominal pain and persistent vomiting as warning signs 347/708: 48(44,51) 86/138: 63(55,71) 132/282: 47(41,52) 129/288: 45(39,50) 0.003
All warning signs listed 181/665: 26(23,30) 44/126: 35(27,44) 75/266: 28(23,33) 62/274: 23(18,28) 0.04
All laboratory tests used to diagnose acute cases of dengue 40/578: 6(4,7) 21/119: 15(10,22) 16/232: 7(4,11) 3/227: 1(0.5,4) <0.001
Hospital Referral Criteria (% who refer for):
Criteria consistent with 1997 Guidelines 216/677: 31(28,34) 47/125: 33(25,41) 101/275: 37(31,42) 68/277: 25(20,30) 0.002
Minor bleeding without shock or hemoconcentration 457/677: 68(64,71) 74/125: 58(49,67) 189/275: 69(63,74) 194/277: 70(65,75) 0.02
Platelet count ≤100,000 without bleeding, hemoconcentration, or shock 213/677: 32(28,35) 32/125: 24(17,32) 106/275: 38(33,44) 75/277: 27(22,32) <0.001

* Percentages incorporate survey design weights, and thus may not equal the crude proportions. Fewer than 12% of respondents failed to answer any individual question; the denominator includes only those who answered the question in order to give the most conservative estimate.

1997 WHO case definition defined dengue as an acute febrile illness of 2 to 7 days duration with 2 or more of the following: headache, retro-orbital pain, myalgia, arthralgia, rash, hemorrhagic manifestations, leucopenia. Warning signs include: severe abdominal pain, persistent vomiting, cold and clammy skin/extremities, narrowing pulse pressure, hypotension, change in mental status (e.g., irritability, lethargy).