. Author manuscript; available in PMC: 2015 Oct 1.

Published in final edited form as: Ann Neurol. 2014 Aug 30;76(4):522–528. doi: 10.1002/ana.24249

Table 1.

Transcriptional deficiency in FRDA is modulated by the shorter of the two expanded GAA-TR alleles containing <400 triplets

		Linear		Piecewise Bilinear Regression
		Regression		Piecewise Bilinear Regression

GAA-TR allele^*	Region	R²	p	R²	p, before breakpoint	Breakpoint (95% C.I.), triplets	p, after breakpoint

Short	Ex1	0.49	0.003	0.84	0.014	423 (353–494)	n.s.

	Ex3-Ex4	0.56	0.001	0.89	0.002	405 (346–464)	n.s.

Average	Ex1	0.57	0.001	0.79	0.021	706 (607–804)	n.s.

	Ex3-Ex4	0.55	0.001	0.68	0.031	730 (564–896)	n.s.

Long	Ex1	0.42	0.007	0.56	0.045	854 (649–1059)	n.s.

	Ex3-Ex4	0.32	0.022	0.38	n.s.	853 (454–1251)	n.s.

Short / long / average refer to the shorter / longer / average of the two expanded GAA-TR alleles; C.I. = confidence interval; n.s. = not significant.