Table 1.
Hazard ratios (HR) for the association of plasma phospholipid α-linolenic acid with the risk of total and cause-specific mortality among 2709 US adults (Hazard ratios and 95 % confidence intervals)
| Quintiles
|
P for trend | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| I | II
|
III
|
IV
|
V
|
||||||
| HR | 95 % CI | HR | 95 % CI | HR | 95 % CI | HR | 95 % CI | |||
| Total mortality | ||||||||||
| Person-years | 6483 | 6025 | 6315 | 6352 | 6936 | |||||
| No. of deaths | 360 | 354 | 359 | 331 | 353 | |||||
| Age- and sex-adjusted | 1·0 (ref.) | 1·08 | 0·93, 1·25 | 1·07 | 0·92, 1·23 | 0·94 | 0·81, 1·10 | 0·91 | 0·79, 1·06 | 0·06 |
| Additionally adjusted model* | 1·0 (ref.) | 1·09 | 0·93, 1·26 | 1·09 | 0·94, 1·27 | 0·95 | 0·81, 1·11 | 0·93 | 0·79, 1·08 | 0·11 |
| Non-CVD mortality | ||||||||||
| No. of deaths | 235 | 229 | 236 | 209 | 229 | |||||
| Age- and sex-adjusted | 1·0 (ref.) | 1·07 | 0·89, 1·28 | 1·08 | 0·90, 1·29 | 0·92 | 0·76, 1·11 | 0·91 | 0·76, 1·09 | 0·10 |
| Additionally adjusted model* | 1·0 (ref.) | 1·09 | 0·90, 1·31 | 1·11 | 0·92, 1·34 | 0·92 | 0·76, 1·11 | 0·90 | 0·75, 1·09 | 0·09 |
| Total CVD mortality | ||||||||||
| No. of deaths | 101 | 108 | 102 | 102 | 106 | |||||
| Age- and sex-adjusted | 1·0 (ref.) | 1·16 | 0·88, 1·52 | 1·07 | 0·81, 1·41 | 1·02 | 0·78, 1·35 | 0·96 | 0·73, 1·27 | 0·50 |
| Additionally adjusted model* | 1·0 (ref.) | 1·15 | 0·87, 1·53 | 1·08 | 0·81, 1·44 | 1·05 | 0·79, 1·40 | 1·02 | 0·77, 1·36 | 0·87 |
| Total CHD mortality | ||||||||||
| No. of deaths | 68 | 64 | 69 | 64 | 66 | |||||
| Age- and sex-adjusted | 1·0 (ref.) | 1·03 | 0·74, 1·46 | 1·11 | 0·79, 1·56 | 0·99 | 0·70, 1·40 | 0·92 | 0·66, 1·30 | 0·59 |
| Additionally adjusted model* | 1·0 (ref.) | 1·06 | 0·75, 1·51 | 1·16 | 0·82, 1·65 | 1·02 | 0·71, 1·45 | 1·03 | 0·72, 1·46 | 0·98 |
| Arrhythmic death | ||||||||||
| No. of deaths | 35 | 30 | 38 | 34 | 33 | |||||
| Age- and sex-adjusted | 1·0 (ref.) | 0·93 | 0·57, 1·52 | 1·16 | 0·73, 1·83 | 1·00 | 0·62, 1·60 | 0·88 | 0·55, 1·42 | 0·72 |
| Additionally adjusted model* | 1·0 (ref.) | 1·02 | 0·62, 1·67 | 1·23 | 0·76, 1·99 | 1·05 | 0·64, 1·71 | 0·98 | 0·60, 1·62 | 0·99 |
| Non-arrhythmic death | ||||||||||
| No. of deaths | 33 | 34 | 31 | 30 | 33 | |||||
| Age- and sex-adjusted | 1·0 (ref.) | 1·14 | 0·71, 1·85 | 1·06 | 0·65, 1·74 | 0·98 | 0·60, 1·62 | 0·97 | 0·59, 1·57 | 0·70 |
| Additionally adjusted model* | 1·0 (ref.) | 1·12 | 0·68, 1·83 | 1·09 | 0·65, 1·81 | 0·99 | 0·59, 1·66 | 1·07 | 0·65, 1·76 | 0·97 |
ref., Reference.
*
Additionally adjusted for race, enrolment site, education, smoking status, diabetes, BMI, waist circumference, physical activity, alcohol consumption and treated hypertension.