Table 2.
Hazard Ratios and Confidence Intervals for each 10% increase in Reflection Magnitude and Death in Unadjusted and Adjusted Models.
| Model | All-Cause Mortality (617 deaths) | Cardiovascular Mortality (134 deaths) | Non-Cardiovascular Mortality (460 deaths) | ||||||
|---|---|---|---|---|---|---|---|---|---|
| Hazard Ratio | Confidence Interval | P-value | Hazard Ratio | Confidence Interval | P-value | Hazard Ratio | Confidence Interval | P-value | |
| Model 1* | 1.31 | 1.11–1.55 | 0.001 | 1.61 | 1.12–2.31 | 0.01 | 1.28 | 1.06–1.55 | 0.01 |
| Model 2† | 1.32 | 1.12–1.56 | 0.001 | 1.61 | 1.13–2.29 | 0.009 | 1.29 | 1.07–1.56 | 0.008 |
| Model 3‡ | 1.18 | 0.97–1.44 | 0.09 | 1.37 | 0.89–2.11 | 0.15 | 1.18 | 0.94–1.48 | 0.14 |
| Model 4§ | 1.23 | 1.01–1.51 | 0.04 | 1.55 | 0.99–2.44 | 0.06 | 1.21 | 0.96–1.53 | 0.11 |
| Model 5|| | 1.22 | 0.98–1.52 | 0.07 | 1.71 | 1.06–2.77 | 0.03 | 1.16 | 0.90–1.49 | 0.26 |
Model 1 – unadjusted (n=5984, 617 total deaths)
Model 2 – adjusted for heart rate (n=5984, 617 total deaths)
Model 3 – Model 2 + adjustment for age, gender, ethnicity, systolic and diastolic blood pressure, eGFR, urinary albumin/creatinine ratio, total cholesterol, LDL cholesterol, HDL cholesterol, treatment with antihypertensive medications, treatment with statins, current smoking status, BMI, family history of myocardial infarction, diabetes mellitus, C-reactive protein, highest level of education, family income, alcohol use, total calories per day, percent of calories from fat, physical activity (n=4825, total 473 deaths)
Model 4 – Model 3 + adjustment for ankle-brachial index, maximum common carotid intima-media thickness, mean phantom-adjusted Agatston coronary calcium score, ascending thoracic aortic Agatston calcium score (n=4762, 464 deaths)
Model 5 – Model 4 + NT-pro-BNP (n=4005, total 394 deaths)