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. Author manuscript; available in PMC: 2015 Apr 9.
Published in final edited form as: Nature. 2014 Aug 3;514(7521):228–232. doi: 10.1038/nature13585

Extended Data Table 2.

p53++;CMV-Cre X p53LSL-25,26,53,54/+

Genotype: Embryonic Age:
E12.5 E15.5 E13.5 E14.5 E18.5
# Observed Progeny (# Expected Progeny)
p53+/+ Live 32 (28) 37 (45) 21 (20) 15 (19) 12 (14)
Dead 1 3 2 0 0
Exencephaly 0 0 0 0 0
p53+/+Cre+ Live 27 (28) 59 (45) 20 (20) 17 (19) 20 (14)
Dead 4 12 3 1 5
Exencephaly 0 0 0 1 0
P53LSL-25,26,53,54/+ Live 26 (28) 38 (45) 18 (20) 24 (19) 9 (14)
Dead 3 3 1 0 0
Exencephaly 0 0 0 0 0
p5325,26,53,54/+ Care+ Live 16 (19) 23* (37) 7 (14) 1** (16) 2* (7)
Dead 3 8 11 6 9
Exencephaly 14 8 2 1 1
p53LSL-25,26,53,54/+ Cre+
No or incomplete recombination
Live 9 8 6 3 7
Dead 1 1 1 0 1
Exencephaly 0 2 0 0 0

n=122 n=192 n=90 n=67 n=65
p=0.290 *p=0.019 p=0.053 **p=1.24E-05 *p=0.047