Extended Data Table 2.
p53++;CMV-Cre X p53LSL-25,26,53,54/+ | ||||||
---|---|---|---|---|---|---|
| ||||||
Genotype: | Embryonic Age: |
|||||
E12.5 | E15.5 | E13.5 | E14.5 | E18.5 | ||
# Observed Progeny (# Expected
Progeny) | ||||||
p53+/+ | Live | 32 (28) | 37 (45) | 21 (20) | 15 (19) | 12 (14) |
Dead | 1 | 3 | 2 | 0 | 0 | |
Exencephaly | 0 | 0 | 0 | 0 | 0 | |
p53+/+Cre+ | Live | 27 (28) | 59 (45) | 20 (20) | 17 (19) | 20 (14) |
Dead | 4 | 12 | 3 | 1 | 5 | |
Exencephaly | 0 | 0 | 0 | 1 | 0 | |
P53LSL-25,26,53,54/+ | Live | 26 (28) | 38 (45) | 18 (20) | 24 (19) | 9 (14) |
Dead | 3 | 3 | 1 | 0 | 0 | |
Exencephaly | 0 | 0 | 0 | 0 | 0 | |
p5325,26,53,54/+ Care+ | Live | 16 (19) | 23* (37) | 7 (14) | 1** (16) | 2* (7) |
Dead | 3 | 8 | 11 | 6 | 9 | |
Exencephaly | 14 | 8 | 2 | 1 | 1 | |
p53LSL-25,26,53,54/+
Cre+ No or incomplete recombination |
Live | 9 | 8 | 6 | 3 | 7 |
Dead | 1 | 1 | 1 | 0 | 1 | |
Exencephaly | 0 | 2 | 0 | 0 | 0 | |
| ||||||
n=122 | n=192 | n=90 | n=67 | n=65 | ||
p=0.290 | *p=0.019 | p=0.053 | **p=1.24E-05 | *p=0.047 |