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. Author manuscript; available in PMC: 2015 Nov 1.
Published in final edited form as: Hypertension. 2014 Sep 2;64(5):1032–1039. doi: 10.1161/HYPERTENSIONAHA.114.03900

Figure 1.

Figure 1

Effect of Bcl10 deficiency on mean arterial pressure (MAP) and angiotensin (Ang) II-induced cardiac damage. (A) Telemetric MAP was elevated during Ang II in both groups. Cardiac hypertrophy assessed by (B) echocardiography as the sum of septal (IVSd) and posterior wall (LVPWd) thickness, (C) heart weight-to-body weight ratio or (D) cardiac hypertrophy marker brain natriuretic peptide (BNP) after 2 weeks of saline or Ang II treatment in the heart of wildtype (WT) and Bcl10 knockout (KO) mice. Number of infiltrating (E, left) CD4+ T cells, (middle) CD8+ T cells and (right) F4/80+ macrophages in the same animals. (F) Perivascular collagen I and (G) interstitial fibronectin and quantification (H and I) of the images of the study animals. Results are mean±SEM. *P<0.05 versus WT and Bcl10 KO, #P<0.05 versus WT+Ang II, one-way ANOVA using Tukey’s post-hoc test, n=4 in untreated groups, n=5 in Bcl10±Ang II and n=9 in WT±Ang II groups.