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. Author manuscript; available in PMC: 2015 Nov 1.
Published in final edited form as: Nucl Med Biol. 2014 Aug 1;41(10):802–812. doi: 10.1016/j.nucmedbio.2014.07.005

Figure 2.

Figure 2

Paired-label in vitro internalization of iso-[125I]SGMIB-Nb (gray) and [131I]SGMIB-Nb (black) by BT474 cells. Cells were allowed to take up the radiotracers at 4°C for an hour, brought up to 37°C and processed at 1 h, 2 h, 4 h, 6 h, and 24 h as described in the text. Specific (in the absence of trastuzumab minus in the presence) total cell-associated radioactivity (cell surface-bound + internalized) (A) and intracellularly trapped activity (B).