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. Author manuscript; available in PMC: 2015 Nov 1.
Published in final edited form as: Nucl Med Biol. 2014 Aug 1;41(10):802–812. doi: 10.1016/j.nucmedbio.2014.07.005

Table 1.

Paired-label uptake of iodine radioactivity in various tissues after intravenous administration of trastuzumab labeled using [131I]SGMIB and iso[125I]SGMIB in SCID mice bearing BT474M1 xenografts.

Tissue %Injected Dose/grama
4 h 12 h 24 h 48 h
SGMIB iso-SGMIB SGMIB iso-SGMIB SGMIB iso-SGMIB SGMIB iso-SGMIB
Liver 19.77 ± 7.12 18.78 ± 6.62 12.59 ± 2.48 11.99 ± 2.39 7.01 ± 1.14 6.69 ± 1.10 5.24 ± 1.77 5.80 ± 1.83b
Spleen 36.71 ± 14.50 37.80 ± 14.85 20.44 ± 5.91 20.69 ± 5.86b 13.14 ± 3.77 13.76 ± 3.41b 5.58 ± 1.75 5.80 ± 1.83
Lung 12.90 ± 3.77 13.71 ± 4.16 10.71 ± 3.97 11.29 ± 4.09 5.18 ± 0.91 5.40 ± 0.96 3.76 ± 0.99 4.01 ± 1.01
Heart 9.90 ± 3.73 10.30 ± 3.65 7.52 ± 2.04 7.85 ± 1.99b 3.40 ± 0.52 3.52 ± 0.53 2.12 ± 0.66 2.22 ± 0.73b
Kidney 11.16 ± 3.55 11.38 ± 3.70 7.85 ± 2.28 8.04 ± 2.32 3.84 ± 0.33 3.85 ± 0.35b 2.63 ± 0.71 2.72 ± 0.71
Stomach 2.99 ± 1.39 3.14 ± 1.47b 1.79 ± 0.62 1.83 ± 0.63 1.37 ± 0.41 1.42 ± 0.45b 0.63 ± 0.33 0.72 ± 0.38
Sm. Intestine 5.22 ± 2.07 5.37 ± 2.16 2.73 ± 0.78 3.13 ± 0.82 1.63 ± 0.19 1.93 ± 0.25 1.05 ± 0.28 1.41 ± 0.44
Intestine 2.83 ± 0.64 2.66 ± 0.67 2.88 ± 0.90 3.66 ± 0.93 2.11 ± 0.26 3.29 ± 0.68 1.11 ± 0.23 1.93 ± 0.43
Muscle 1.92 ± 0.77 1.99 ± 0.79b 2.16 ± 0.85 2.31 ± 0.88 1.47 ± 0.15 1.53 ± 0.17 0.89 ± 0.17 0.94 ± 0.17
Blood 27.80 ± 12.18 28.18 ± 12.53b 19.93 ± 6.93 20.09 ± 6.63b 9.05 ± 0.87 9.13 ± 0.96b 5.35 ± 1.45 5.63 ± 1.59
Bone 3.72 ± 1.14 3.75 ± 1.04b 2.68 ± 0.79 2.71 ± 0.86b 1.66 ± 0.57 1.67 ± 0.56b 1.12 ± 0.35 1.10 ± 0.33b
Brain 1.11 ± 0.32 1.17 ± 0.36 0.84 ± 0.34 0.87 ± 0.35 0.33 ± 0.05 0.34 ± 0.06b 0.20 ± 0.04 0.21 ± 0.04b
Tumor 10.97 ± 4.34 10.65 ± 4.10 16.82 ± 5.20 15.26 ± 4.60 17.89 ± 3.24 15.08 ± 2.41 12.83 ± 2.22 10.06 ± 1.43
a

Mean ± SD (n = 5).

b

Difference between the uptake of two isotopes not statistically significant.