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. Author manuscript; available in PMC: 2015 Nov 1.
Published in final edited form as: Steroids. 2014 Jun 17;90:3–12. doi: 10.1016/j.steroids.2014.06.009

Fig. 6.

Fig. 6

Progress toward an ideal SERM. The overall good or bad aspects of administering hormone replacement therapy (HRT) to postmenopausal women compared with the observed site-specific actions of the SERMs tamoxifen and raloxifene. The known beneficial or negative actions of SERMs have opened the door for drug discovery to create the ideal SERM or targeted SERMs to either improve quality of life or prevent diseases associated with aging in women. This figure is published with permission from Elsevier. Jordan, V.C. Selective estrogen receptor modulation: Concept and consequences in cancer. Cancer Cell, 2004 Mar; 5(3): 207–213.