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. Author manuscript; available in PMC: 2016 May 1.
Published in final edited form as: Addict Biol. 2014 Apr 9;20(3):469–481. doi: 10.1111/adb.12139

Figure 9.

Figure 9

Blockade of orexin 2 receptor (OX2R) but not orexin 1 receptor (OX1R) activity in the anterior paraventricular thalamus (aPVT) but not posterior paraventricular thalamus (pPVT) decreases intermittent-access 20% ethanol drinking. A. Ethanol drinking in rats injected in the aPVT with 0.3 µl of the OX1R antagonist SB 334867 (10 nmol) or dimethyl sulfoxide vehicle (Set 5, n = 6). B. Drinking in rats injected in the aPVT with 0.3 µl of the OX2R antagonist TCS OX2 29 (10 nmol) or saline vehicle (Set 5, n = 6). C. Ethanol drinking in rats injected in the pPVT with SB 334867 or vehicle (Set 5, n = 6). D. Drinking in rats injected in the pPVT with TCS OX2 29 or vehicle (Set 5, n = 6). Effects were no longer evident at four hours post-injection (data not shown). *p < 0.05 vs. vehicle.