Fig. 5.

Thickness heat maps of AC obtained from PTA-CT datasets of the 4-weeks DMM group (CTRL and DMM side). A–B, Mediolateral (A) and medial anteroposterior (B) thickness maps of the AC for a representative pair of CTRL and DMM tibiae. Below each panel the red profiles show the changes in thickness along the horizontal bars highlighted on the maps (each profile is the average of four samples). Thickness profiles of naïve mice (n = 6) are displayed in black (maps not shown for naïve mice). The position of the automated ROIs on the maps is indicated by dashed squares. Note that the peak thickness fall in the automated ROIs and is markedly decreased 12 weeks post DMM surgery. The arrow head shows a second peak in AC thickness in the mediolateral DMM profile, presumably due to the newly formed cartilage covering a medial osteophyte.