Table 3.
Summary of outcome in reported pregnancies with anti Cw
Reference | No of cases | Clinical outcome |
---|---|---|
Lawler and Loghem [3] | 1 | HDN |
Anderson et al. [4] | 9 pregnancies in a anti Cw positive woman | First child normal, Cw positive |
Second and third child (twins) had jaundice, Cw positive, required transfusion | ||
Fourth child normal, Cw negative | ||
Next four pregnancy miscarriage | ||
Fifth child had jaundice, Cw positive, no transfusion required | ||
Hughes et al. [5] | NM | Severe HDF, treated with phototherapy and exchange transfusion |
Bowman et al. [6] | 14 pregnancies with acquired anti Cw (In 1 in 1,100 women treated during 36 years) | Three babies who were Cw negative- normal |
11 babies were Cw positive- DAT+had HDN | ||
(Five no treatment required, two required phototherapy and four required exchange transfusion) | ||
Reiner et al. [7] | 1 | Required phototherapy and exchange transfusion |
Kollamparambil et al. [8] | NM | Severe HDF, fetus had hydrops. |
Byers et al. [9] | 1 | Severe fetal anemia requiring intrauterine transfusion |
May-Wewers et al. [10] | 1 | Severe neonatal anemia |
Chu et al. [11] | NM | History of previous IUD and bad obstetrics history. Presenting pregnancy had HDN and neonate required exchange transfusion |
Malik [12] | 1 (Primi) | Normal baby |
1 (4th gravida) | Normal baby | |
1 (Primi) | NM |
DAT direct ant globulin test, NM not mentioned, IUD intra uterine transfusion, HDF hemolytic disease of fetus, HDN hemolytic disease of newborn