Table 3.
Summary of outcome in reported pregnancies with anti Cw
| Reference | No of cases | Clinical outcome |
|---|---|---|
| Lawler and Loghem [3] | 1 | HDN |
| Anderson et al. [4] | 9 pregnancies in a anti Cw positive woman | First child normal, Cw positive |
| Second and third child (twins) had jaundice, Cw positive, required transfusion | ||
| Fourth child normal, Cw negative | ||
| Next four pregnancy miscarriage | ||
| Fifth child had jaundice, Cw positive, no transfusion required | ||
| Hughes et al. [5] | NM | Severe HDF, treated with phototherapy and exchange transfusion |
| Bowman et al. [6] | 14 pregnancies with acquired anti Cw (In 1 in 1,100 women treated during 36 years) | Three babies who were Cw negative- normal |
| 11 babies were Cw positive- DAT+had HDN | ||
| (Five no treatment required, two required phototherapy and four required exchange transfusion) | ||
| Reiner et al. [7] | 1 | Required phototherapy and exchange transfusion |
| Kollamparambil et al. [8] | NM | Severe HDF, fetus had hydrops. |
| Byers et al. [9] | 1 | Severe fetal anemia requiring intrauterine transfusion |
| May-Wewers et al. [10] | 1 | Severe neonatal anemia |
| Chu et al. [11] | NM | History of previous IUD and bad obstetrics history. Presenting pregnancy had HDN and neonate required exchange transfusion |
| Malik [12] | 1 (Primi) | Normal baby |
| 1 (4th gravida) | Normal baby | |
| 1 (Primi) | NM |
DAT direct ant globulin test, NM not mentioned, IUD intra uterine transfusion, HDF hemolytic disease of fetus, HDN hemolytic disease of newborn