Table 2.

Body Weights, LBWR, GTT Values, Serum Transaminase Levels, Circulating and Hepatic FFA Levels, and α-SMA Expression in WT, 5αR1^−/−, and 5αR2^−/− Mice Fed ALIOS Diet for 6 or 12 Months^a

	6 Months		12 Months		6 Months		12 Months
	WT	5αR1−/−	WT	5αR1−/−	WT	5αR2−/−	WT	5αR2−/−
Body weight, g	38.5 ± 3.6	42.6 ± 1.4	46.2 ± 3.9	43.7 ± 1.6	37.0 ± 2.4	43.5 ± 1.0b	42.5 ± 5.7	40.6 ± 2.8
LBWR	0.05 ± 0.01	0.09 ± 0.01b	0.10 ± 0.01	0.10 ± 0.01	0.05 ± 0.00	0.05 ± 0.00	0.12 ± 0.01	0.09 ± 0.01
Fasting glucose, mmol/L	9.6 ± 1.2	9.3 ± 0.8	8.4 ± 0.3	8.3 ± 0.4	9.1 ± 0.4	9.7 ± 0.8	8.8 ± 1.2	9.1 ± 0.9
2 h glucose, mmol/L	21.9 ± 4.9	20.3 ± 3.6	23.5 ± 3.2	19.3 ± 1.8	15.3 ± 1.1	20.2 ± 3.5	15.1 ± 2.9	17.7 ± 5.2
GTT AUC, mmol/L·h	1604 ± 181	1047 ± 211	2519 ± 254	2164 ± 171	1349 ± 95	1700 ± 294	1709 ± 190	2248 ± 460
AST, IU/L	171 ± 71	482 ± 158	427 ± 73	359 ± 91	151 ± 23	125 ± 25	231 ± 44	265 ± 46
ALT, IU/L	140 ± 88	352 ± 116	303 ± 38	336 ± 37	86 ± 21	60 ± 13	202 ± 62	156 ± 41
AST/ALT ratio	1.97 ± 0.4	1.45 ± 0.1	1.39 ± 0.2	0.72 ± 0.2b	2.73 ± 0.3	2.33 ± 0.5	1.75 ± 0.8	2.6 ± 0.8
Circulating FFA, nmol/μl	0.46 ± 0.07	0.55 ± 0.06	0.57 ± 0.06	0.46 ± 0.04	0.50 ± 0.03	0.44 ± 0.06	0.48 ± 0.09	0.30 ± 0.07
Hepatic FFA, nmol/mg	1.90 ± 0.15	1.66 ± 0.07	1.81 ± 0.14	1.97 ± 0.14
α-SMA, % positive area			2.26 ± 0.4	2.29 ± 0.1			1.64 ± 0.4	1.28 ± 0.14

Abbreviation: AUC, area under the curve.

^aAll data are expressed as mean ± SEM.

^bP < .05 vs WT.