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. 2013 Oct 29;154(12):4580–4593. doi: 10.1210/en.2013-1613

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Copyright © 2013 by The Endocrine Society

This article has been published under the terms of the Creative Commons Attribution License (CC-BY), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Copyright for this article is retained by the author(s). Author(s) grant(s) the Endocrine Society the exclusive right to publish the article and identify itself as the original publisher.

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Figure 1. — The small molecule 11β-HSD1 inhibitor, compound C, lowers body weight, food intake, and glucose in obese mice. A, Structure of compound C. B, Percentage body weight change over 20 days of treatment. ○, vehicle mice; □, 50 mg/kg/d compound C; ■, 200 mg/kg/d compound C. C, Percentage body weight change on day 20. D, Cumulative food intake over the first 20 days of treatment. E, Fasting glucose levels on treatment day 21. F, Fed leptin levels in terminal plasma taken on treatment day 25. Data are expressed as means ± SEM; n = 7 to 10. *, P < .05; ***, P < .001.