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. 2014 Oct 9;9(10):e109782. doi: 10.1371/journal.pone.0109782

Figure 5. Correlation analysis of preoperative miR-545/374a serum expression with prognosis/diagnosis-related clinical features.

Figure 5

(A) Correlation analysis of preoperative miR-545/374a serum levels with the prognosis-related clinical features of histological grade and metastasis. The histological grade was classified by pathological analysis as good, moderate or poor. Sera levels of miR-545/374a were analyzed by quantitative RT-PCR. The error bars in A represent mean ± Std. deviation. (B) Correlation analysis of preoperative miR-545/374a serum levels with the diagnosis-related clinical feature of AFP. The correlation analysis of CEA and γ-GT with the levels of miR-545/374a are shown in figure S1B. The error bars in B represent mean ± Std. deviation. (C) Gender-based investigation of Ftx microRNA cluster expression. HCC subjects and negative control subjects were grouped according to gender. MicroRNA 545 and miR-374a expression in HCC tissue was assayed by quantitative RT-PCR and compared between these groups. The error bars in C represent mean ± Std. deviation.*P<0.05, **P<0.01, t test. (D) Putative sex-related miR-545 and miR-374a target genes. The sequences comprising the miR-545 and miR-374a target sites are shown. (E) Correlation between HCC tissue miR-545/374a expression and ESRRG gene expression. The levels of miR-545/374a and ESRRG were monitored in 66 HCC tissue samples by quantitative RT-PCR. The correlation analysis of ESRRA and ARGLU-1 with miR-545/374a are shown in figure S1C. *P<0.05, Pearson's correlation test.