Table 3.
Paired comparison of minimum inhibitor concentrations of Isoniazid for the modified and classic resazurin microtiter assays for detection of drug susceptibility in Mycobacterium tuberculosis
| Isoniazid | ||||||||
|---|---|---|---|---|---|---|---|---|
| Modified REMA MIC | ||||||||
| MIC | 0.03125 | 0.0625 | 0.125 | 0.25 | 0.5 | 1 | ≥2 | |
| Classic REMA MIC | 0.03125 | 1 | 2 | 3 | 1 | 1 | 3 | 14 |
| 0.0625 | 0 | 1 | 1 | 0 | 0 | 0 | 12 | |
| 0.125 | 0 | 0 | 0 | 1 | 0 | 0 | 29 | |
| 0.25 | 1 | 0 | 0 | 0 | 0 | 0 | 9 | |
| 0.5 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | |
| 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | |
| 2 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | |
κ = 0.02.
REMA: Resazurin microtiter assay; MIC: minimum inhibitory concentration measured in mg/ml.