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. 2014 Oct 1;12:284. doi: 10.1186/s12967-014-0284-0

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© Xu et al.; licensee BioMed Central Ltd. 2014

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Effect of simvastatin on maxilla of cemento-enamel junction (CEJ) to alveolar bone crest (ABC). (A) Buccal and palatal sides of the maxilla, where alveolar bone loss (ABL, colored lines) was measured from the CEJ to the ABC at four points: mesiolingual (ML), mesiobuccal (MB), distolingual (DL), and distobuccal (DB) regions for first maxillary molar (M1) and second maxillary molar (M2). The region of interest (ROI) is a cuboidal bone body that encompasses the roots of the M1 and M2. (B–D) Analysis of the CEJ-ABC linear distance after 2 months of simvastatin or placebo treatment. Values are expressed as the mean ± the standard deviation (N = 12; * indicates p < 0.05).