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. 2014 Aug 20;289(41):28149–28159. doi: 10.1074/jbc.M114.593103

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© 2014 by The American Society for Biochemistry and Molecular Biology, Inc.

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FIGURE 6. — Cadmium increases macroscopic current amplitude in K95C and K95C/S1141C channels in a gating-dependent manner. A, sample time courses and I-V curves showing Cd²⁺ concentration-dependent increases in macroscopic current amplitude in K95C (left panels) and K95C/S1141C (right panels) channels in inside-out patches. Experiments were performed as described in the legend for Fig. 2. Note that although currents were increased by Cd²⁺, they were inhibited by CFTR_inh-172 (5 μm). B, concentration-dependent increases in current amplitude in K95C were not observed in K95C/E1371Q. Asterisks indicate a significant difference from K95C (p < 0.05). C, Cd²⁺ causes a significantly greater increase in K95C/S1141C current amplitude as compared with K95C (p < 0.0001); this increase is not observed in K95C/S1141C/E1371Q channels. Error bars indicate the means ± S.E. from 3–6 patches.