LSL-PrRP Mice Are Resistant to Leptin’s Thermogenic Actions
(A and B) Preobese mice lacking PrRP (LSL-PrRP) do not respond to leptin with an increase in body temperature (6 weeks old, n = 8 per group, bars represent mean ± SEM; two-way ANOVA, ∗∗∗p < 0.001).
(C) Leptin significantly decreases nocturnal food intake in wt mice, but this effect is abolished in LSL-PrRP mice (6 to 7 weeks old, 2 hr food intake data; n = 6 per group, bars represent mean ± SEM; one-way ANOVA, ∗∗p < 0.01).
(D) CCK causes a dose-dependent decrease in nocturnal food intake in wt mice, but this effect is abolished in LSL-PrRP mice (6 weeks old, 1 hr food intake data; n = 6 per group, bars represent mean ± SEM; one-way ANOVA, ∗∗∗p < 0.001).