Table 3. Average ± SD values from DTI indices (FA, MD, and RD) and normalized volume from gray and white matter regions of the brain between wild type (n = 8) and NL-3 (n = 5) mice at 70 days of age.
| # | Regions | FA | MD×10−3 | RD | Normalize brain volume | ||||
| WT | NL-3 | WT | NL-3 | WT | NL-3 | WT | NL-3 | ||
| 1 | Lat ventricle | 0.31±0.03 | 0.29±0.02 | 0.26±0.04 | 0.30±0.03 | 0.24±0.04 | 0.27±0.04 | 0.20±0.01 | 0.21±0.02 |
| 2 | Hippo CA3 | 0.27±0.04 | 0.24±0.02 | 0.25±0.03 | 0.25±0.02 | 0.23±0.03 | 0.24±0.02 | 0.21±0.01 | 0.21±0.02 |
| 3 | Hippo CA1 | 0.29±0.03 | 0.27±0.02 | 0.26±0.02 | 0.27±0.02 | 0.24±0.02 | 0.24±0.02 | 0.16±0.01 | 0.17±0.01 |
| 4 | Hippo dent gyr | 0.27±0.04 | 0.24±0.02 | 0.28±0.03 | 0.28±0.03 | 0.26±0.03 | 0.26±0.02 | 0.19±0.02 | 0.19±0.01 |
| 5 | Hippo gen | 0.30±0.03 | 0.28±0.02 | 0.25±0.02 | 0.25±0.02 | 0.22±0.02 | 0.23±0.02 | 0.18±0.01 | 0.19±0.01 |
| 6 | Olfact system | 0.23±0.02 | 0.25±0.02 | 0.25±0.02 | 0.25±0.02 | 0.23±0.02 | 0.23±0.02 | 0.81±0.17 | 0.89±0.15 |
| 7 | Frontal cortex | 0.22±0.02 | 0.23±0.02 | 0.25±0.02 | 0.24±0.02 | 0.23±0.02 | 0.23±0.02 | 0.42±0.02 | 0.43±0.01 |
| 8 | Perirh cortex | 0.26±0.03 | 0.26±0.03 | 0.25±0.02 | 0.24±0.02 | 0.24±0.02 | 0.23±0.02 | 0.09±0.01 | 0.10±0.01 |
| 9 | Entorhi cortex | 0.21±0.02 | 0.20±0.02 | 0.27±0.01 | 0.26±0.01 | 0.25±0.01 | 0.26±0.01 | 0.25±0.03 | 0.26±0.02 |
| 10 | Cortex general | 0.26±0.02 | 0.25±0.02 | 0.24±0.01 | 0.24±0.01 | 0.23±0.01 | 0.23±0.01 | 0.75±0.04 | 0.75±0.01 |
| 11 | Caud putamen | 0.21±0.02 | 0.21±0.02 | 0.24±0.02 | 0.23±0.02 | 0.23±0.02 | 0.22±0.02 | 0.44±0.02 | 0.44±0.01 |
| 12 | B gang general | 0.26±0.01 | 0.25±0.02 | 0.22±0.02 | 0.22±0.02 | 0.21±0.02 | 0.21±0.02 | 0.26±0.01 | 0.26±0.01 |
| 13 | Corpus callosum | 0.53±0.02 | 0.52±0.02 | 0.17±0.02 | 0.17±0.02 | 0.13±0.02 | 0.13±0.02 | 0.26±0.01 | 0.26±0.01 |
| 14 | Ant commissure | 0.48±0.02 | 0.48±0.03 | 0.19±0.02 | 0.20±0.03 | 0.1 5±0.01 | 0.15±0.02 | 0.04±0.03 | 0.04±0.03 |
| 15 | Lat olfact tract | 0.26±0.03 | 0.28±0.03 | 0.26±0.02 | 0.25±0.02 | 0.24±0.02 | 0.22±0.01 | 0.05±0.01 | 0.05±0.01 |
| 16 | Internal capsule | 0.53±0.03 | 0.51±0.03 | 0.19±0.03 | 0.18±0.03 | 0.14±0.02 | 0.14±0.02 | 0.11±0.01 | 0.10±0.02 |
| 17 | Amygdala | 0.21±0.02 | 0.21±0.02 | 0.25±0.01 | 0.25±0.02 | 0.24±0.01 | 0.24±0.02 | 0.32±0.02 | 0.32±0.02 |
| 18 | Third ventricle | 0.21±0.03 | 0.20±0.03 | 0.28±0.03 | 0.27±0.04 | 0.27±0.03 | 0.26±0.04 | 0.10±0.04 | 0.10±0.01 |
| 19 | Thalamus | 0.34±0.06 | 0.31±0.01 | 0.21±0.04 | 0.21±0.02 | 0.19±0.04 | 0.20±0.02 | 0.44±0.01 | 0.42±0.02 |
| 20 | Hypothalamus | 0.24±0.02 | 0.24±0.03 | 0.19±0.01 | 0.21±0.03 | 0.18±0.01 | 0.20±0.03 | 0.20±0.01 | 0.20±0.01 |
| 21 | Cereb aqueduct | 0.22±0.04 | 0.22±0.03 | 0.39±0.07 | 0.29±0.07 | 0.38±0.08 | 0.28±0.07 | 0.30±0.03 | 0.31±0.04 |
| 22 | Substantia nigra | 0.38±0.04 | 0.36±0.02 | 0.20±0.03 | 0.21±0.03 | 0.21±0.02 | 0.22±0.01 | 0.07±0.01 | 0.07±0.01 |
| 23 | Sup+Inf colli | 0.25±0.03 | 0.24±0.01 | 0.23±0.02 | 0.23±0.02 | 0.22±0.02 | 0.22±0.02 | 0.35±0.02 | 0.35±0.01 |
| 24 | Periaqued Gray | 0.25±0.05 | 0.23±0.01 | 0.20±0.03 | 0.22±0.03 | 0.19±0.03 | 0.21±0.03 | 0.13±0.01 | 0.13±0.01 |
| 25 | Midbrain general | 0.32±0.04 | 0.30±0.02 | 0.22±0.03 | 0.22±0.03 | 0.20±0.03 | 0.20±0.02 | 0.38±0.02 | 0.38±0.01 |
| 26 | Cereb general | 0.31±0.01 | 0.31±0.02 | 0.21±0.01 | 0.22±0.01 | 0.21±0.01 | 0.22±0.02 | 0.58±0.03 | 0.58±0.02 |
| 27 | Fourth ventricle | 0.22±0.02 | 0.23±0.02 | 0.44±0.06 | 0.38±0.05 | 0.43±0.06 | 0.38±0.05 | 0.11±0.01 | 0.12±0.02 |
| 28 | Pons | 0.33±0.02 | 0.33±0.03 | 0.25±0.02 | 0.24±0.03 | 0.22±0.02 | 0.22±0.02 | 0.64±0.02 | 0.66±0.03 |
| 29 | Medulla | 0.29±0.02 | 0.29±0.02 | 0.26±0.02 | 0.24±0.02 | 0.23±0.02 | 0.22±0.02 | 0.61±0.11 | 0.69±0.04 |
| 30 | Optic nerve | 0.41±0.02 | 0.41±0.04 | 0.27±0.02 | 0.24±0.03 | 0.23±0.02 | 0.20±0.02 | 0.06±0.01 | 0.06±0.01 |
| 31 | Fornix system | 0.51±0.03 | 0.49±0.03 | 0.19±0.03 | 0.19±0.03 | 0.14±0.02 | 0.15±0.02 | 0.13±0.01 | 0.13±0.01 |
| 32 | Pituitary | 0.28±0.05 | 0.27±0.06 | 0.19±0.03 | 0.19±0.03 | 0.14±0.02 | 0.15±0.02 | 0.03±0.01 | 0.03±0.01 |
| 33 | Septum | 0.26±0.03 | 0.24±0.03 | 0.22±0.03 | 0.22±0.02 | 0.20±0.03 | 0.21±0.02 | 0.08±0.01 | 0.08±0.01 |
| 34 | Motor cortex | 0.22±0.01 | 0.21±0.02 | 0.24±0.02 | 0.25±0.01 | 0.28±0.02 | 0.23±0.01 | 0.29±0.02 | 0.29±0.01 |
| 35 | Somatosen cortex | 0.21±0.02 | 0.20±0.02 | 0.24±0.02 | 0.24±0.01 | 0.23±0.01 | 0.23±0.01 | 0.71±0.02 | 0.68±0.02 |
| 36 | Auditory cortex | 0.24±0.03 | 0.22±0.01 | 0.25±0.02 | 0.24±0.01 | 0.23±0.02 | 0.23±0.01 | 0.12±0.01 | 0.12±0.01 |
| 37 | Visual cortex | 0.20±0.02 | 0.19±0.01 | 0.25±0.01 | 0.24±0.01 | 0.24±0.01 | 0.23±0.01 | 0.34±0.01 | 0.32±0.01 |
| 38 | Cerebellar cortex | 0.27±0.01 | 0.27±0.02 | 0.25±0.02 | 0.24±0.01 | 0.24±0.02 | 0.23±0.01 | 0.84±0.04 | 0.83±0.04 |
| 39 | Cereb peduncle | 0.54±0.04 | 0.51±0.04 | 0.24±0.04 | 0.26±0.03 | 0.18±0.04 | 0.21±0.02 | 0.45±0.01 | 0.44±0.01 |
FA = fractional anisotropy, MD = mean diffusivity, RD = radial diffusivity, WT = wild type.
[Lat ventricle = lateral ventricle; Hippo CA3 = hippocampus CA3, Hippo CA1 = hippocampus CA1, Hippo dent gyr = hippocampus dentate gyrus, Hippo gen = hippocampus general, Olfact system = olfactory system, Perirh cortex = perirhinal cortex, Entorhi cortex = entorhinal cortex, Caud putamen = caudate putamen, B gang general = basal ganglia general, Ant commissure = anterior commissure, Lat olfact tract = lateral olfactory tract, Cereb aqueduct = cerebral aqueduct, Sup+Inf colli = superior and inferior collicus, Periaqued gray = periaqueductal gray matter, Cereb general = cerebellum general, Somatosen cortex = somatosensory cortex, Cereb peduncle = cerebral peduncle].