Table 1. Localization of luciferase expression in VSV-G pseudotyped LICh reporter inoculated Rhesus Macaques.
Distribution of infection throughout the FRT | ||||||
Animal | Hormone Treatment | Ovary | Vagina | Ecto-cervix | Endo-cervix | Lymph Node |
FM27 | Untreated | + | + | |||
IB89 | Untreated | + | + | |||
FM16 | Untreated | + | + | |||
FM28 | Untreated | + | + | + | ||
EI91 | DepoProvera | + | ||||
FM34 | DepoProvera | + | + | + | + | + |
LICh reporter vector could reach viable cells throughout the reproductive tract and access local draining lymph nodes.