Table 3. GPF1- or CNF2-dependent genes encoding known virulence factors.

Gene locus (MG8)	Gene	Δgpf1 a	Δcnf2 a	Virulence on plants/Function	Reference
MGG_00365	MAGB	-	−1.58	Reduced virulence/G-protein signaling	[48]
MGG_00466	MoCDC42	−1.52	−2.00	Reduced virulence/CDC42	[74]
MGG_00501	TGD2	−1.67	−2.68	Reduced virulence/Transcription factor	[15], [72], [83]
MGG_00692	MSTU1	−7.80	−11.85	Reduced virulence/Transcription factor	[8]
MGG_00800	MST7	−2.00	−1.67	No virulence/MAPK pathway	[52]
MGG_00803	MoSNF1	−1.43	−1.79	Reduced virulence/Glucose derepression pathway	[62]
MGG_00883	MoMCK1	−1.39	−1.52	No virulence/MAPK pathway	[53]
MGG_01057	MoLDB1	−1.63	−2.18	Reduced virulence/Transcription factor	[18]
MGG_01204	MoMIG1	-	−1.95	No virulence/Transcription factor	[20]
MGG_01230	MoSSADH	−1.54	-	Reduced virulence/γ-aminobutyric acid degradation	[23]
MGG_01282		1.46	2.26	No virulence/polyubiquitin	[84]
MGG_01558	SET3	-	−1.53	No virulence/Set3 complex	[85]
MGG_01662	MoAAT	-	−1.56	Reduced virulence/4-aminobutyrate aminotransferase	[23]
MGG_01663	HOS2	−1.46	−1.51	No virulence/Set3 complex	[85]
MGG_02531	MoVPR	−3.04	−3.00	Reduced virulence	[23]
MGG_02731	MoRAC1	-	−1.45	Reduced virulence/Small GTPase	[86]
MGG_02848	MC69	−1.57	-	Reduced virulence/Secreted proteins	[87]
MGG_02897	Mossk1	-	−1.81	Reduced virulence/Response regulator	[79]
MGG_03065	MoVMA11	−1.53	-	No virulence/ATPase	[46]
MGG_03694	MoATG6	−1.39	-	No virulence/Autophagy	[88]
MGG_04050	MoSEC22	−2.81	−3.80	No virulence/R-Snare	[89]
MGG_04895	ICL1	−1.72	−1.59	Reduced virulence/Glyoxylate cycle	[63]
MGG_04943	MoMPS1	-	−1.75	No virulence/MAPK pathway	[54]
MGG_05133	MoCRZ1	-	−1.42	Reduced virulence/Ca2+ signaling	[9], [90]
MGG_05201	MGB1	−1.67	−1.80	No virulence/G-protein signaling	[51]
MGG_05287	CON7	-	−1.93	No virulence/Transcription factor	[12]
MGG_05428	MoVAM7	-	−1.89	No virulence/Snare	[91]
MGG_05664	MoPDEH	-	−1.77	Reduced virulence/cAMP signaling	[92]
MGG_05755	MoMON1	1.38	-	No virulence/Vacuole and vesicle fusion	[93]
MGG_06033	MoMSB2	-	−1.78	Reduced virulence/Signaling	[94]
MGG_06249	MoTCTP	-	1.43	Reduced virulence/Mitochondrial protein	[80]
MGG_06393	MoATG1	−1.36	−1.51	No virulence/Autophagy	[55]
MGG_06439	MoTEA4	−1.88	−2.26	Reduced virulence	[95]
MGG_06564	MoPAC2	-	−1.67	Reduced virulence/Transcription factor	[96]
MGG_06868	ILV2	4.24	4.03	Reduced virulence/Amino acid metabolic pathway	[61]
MGG_06971	MoSFL1	-	−1.73	Reduced virulence/Transcription factor	[22]
MGG_07460	MoHYR1	1.73	2.32	Reduced virulence/Reactive oxygen species	[59]
MGG_08212	MoATF1	1.42	-	Reduced virulence/Transcription factor	[24]
MGG_08850	MoGTI1	−1.58	−2.55	Reduced virulence/Stress	[96]
MGG_08895	GTR1	2.06	1.82	Reduced virulence/Reactive oxygen species	[60]
MGG_09125	MoSHO1	-	−1.80	Reduced virulence/Signaling	[94]
MGG_09262	MoATG5	7.64	8.88	No virulence/Autophagy	[56]
MGG_09559	MoATG9	−1.41	−1.42	No virulence/Autophagy	[57]
MGG_09565	PMK1	−1.49	−1.93	No virulence/MAPK pathway	[52]
MGG_09912	MoCMK1	−1.75	−1.46	Reduced virulence/Ca2+ signaling	[97]
MGG_10315	MPG1	−12.49	−15.83	Reduced virulence/Hydrophobin	[75]
MGG_10323	MoRHO3	−1.46	−1.69	No virulence/Small GTPase	[98]
MGG_11346	MoCDTF1	-	−1.72	No virulence/Transcription factor	[19]
MGG_12828	MoATG15	1.48	-	No virulence/Autophagy	[88]
MGG_12832	SNX41	−1.36	-	No virulence/Autophagy	[58]
MGG_12865	PTH12	2.97	2.09	No virulence/Transcription factor	[16], [47]
MGG_12868	ECH1	-	1.47	Reduced virulence/Enoyl-CoA hydratase	[99]
MGG_12958	MST12	-	−1.71	No virulence/Transcription factor	[21]
MGG_13624	MoABC1	-	−1.59	No virulence/ABC transporter	[100]
MGG_14014	MoPLAA	2.12	2.09	Reduced virulence/Lipid metabolism	[64]
MGG_14517	MoFLBA	-	−1.69	Reduced virulence/G-protein signaling	[49], [50], [101]
MGG_14847	MST11	-	−1.33	No virulence/MAPK pathway	[52]

Note:

^a) The expression of genes increased or decreased in Δgpf1 and Δcnf2.

The number means the fold change, and the symbol “−” means no significant change (FDR<0.05) afterwards compared with the wild-type strain.