Table 3.
Interaction of Age at Menarche and Menstrual Characteristics with Body Mass Index on Adult Onset Asthma
| Adult onset asthma | Stratified model | Joint model | |||||
|---|---|---|---|---|---|---|---|
| Characteristics | Yes (N=257) |
No (N=3151) |
Adj. RR | 95% (CI) | Adj. RR | 95% (CI) | |
| BMI at age 18 and age at menarche | |||||||
| <25kg/m2,> 11 years | 191 (81.28) | 2564 (86.92) | Referent | Referent | Referent | Referent | |
| <25kg/m2,≤ 11 years | 44 (18.72) | 386 (13.08) | 1.52 | (1.10,2.08) | 1.5 | (1.11,2.05) | |
| ≥25kg/m2,> 11 years | 12 (54.55) | 145 (72.14) | Referent | Referent | 1.1 | (0.62,1.94) | |
| ≥25kg/m2,≤ 11 years | 10 (45.45) | 56 (27.86) | 1.99 | (0.87,4.55) | 2.18 | (1.19,3.98) | |
| P-value for interaction | 0.523 | ||||||
| BMI at age 18 and menstrual regularity | |||||||
| <25kg/m2, regular menses | 198 (86.46) | 2513 (85.19) | Referent | Referent | Referent | Referent | |
| <25kg/m2, irregular menses | 31 (13.54) | 437 (14.81) | 0.91 | (0.63,1.31) | 0.91 | (0.63,1.31) | |
| ≥25kg/m2, regular menses | 18 (81.82) | 176 (87.56) | Referent | Referent | 1.25 | (0.78,2.00) | |
| ≥25kg/m2,irregular menses | 4 (18.18) | 25 (12.44) | 1.59 | (0.57,4.44) | 1.84 | (0.73,4.63) | |
| P-value for interaction | 0.384 | ||||||
| BMI at age 18 and usual cycle length | |||||||
| <25kg/m2, < 36 days | 208 (90.83) | 2715 (92.50) | Referent | Referent | Referent | Referent | |
| <25kg/m2, ≥36 days | 21 (9.17) | 220 (7.50) | 1.23 | (0.80,1.89) | 1.23 | (0.80,1.89) | |
| ≥25kg/m2, <36 days | 20 (90.91) | 182 (91.46) | Referent | Referent | 1.36 | (0.87,2.13) | |
| ≥25kg/m2, ≥36 days | 2 (9.09) | 17 (8.54) | 1.07 | (0.26,4.31) | 1.51 | (0.41,5.66) | |
| P-value for interaction | 0.886 | ||||||
Adjusted for – age, race/ethnicity, educational status, smoking, physical activity between ages 13 – 17yrs, parity, history of diabetes and history of hypertension