Table 1.
Heart and body weights as well as tibia lengths of rats after 2, 6, 10 and 20 weeks of pressure overload compared to control
| 2 weeks | 6 weeks | 10 weeks | 20 weeks | |||||
|---|---|---|---|---|---|---|---|---|
| Sham | AoB | Sham | AoB | Sham | AoB | Sham | AoB | |
| BW (g) | 132.5 ± 6.6 | 116.5 ± 2.4 | 237.8 ± 6.7 | 235.9 ± 17.3 | 357.5 ± 10.8 | 349.8 ± 15.1 | 454.1 ± 22.7 | 419.5 ± 11.0 |
| HW (mg) | 494 ± 15 | 779 ± 81** | 827 ± 18 | 1701 ± 63*** | 1130 ± 25 | 2053 ± 85*** | 1282 ± 43 | 2273 ± 125*** |
| HW/BW (mg g−1) | 3.75 ± 0.14 | 6.67 ± 0.62** | 3.49 ± 0.09 | 7.31 ± 0.40*** | 3.18 ± 0.08 | 5.90 ± 0.19*** | 2.84 ± 0.11 | 5.43 ± 0.28*** |
| TL (mm) | 25.0 ± 0.5 | 24.0 ± 0.5 | 30.1 ± 0.3 | 31.0 ± 0.7 | 34.9 ± 0.5 | 36.7 ± 0.4** | 40.2 ± 0.7 | 41.1 ± 0.8 |
| HW/TL (mg mm−1) | 19.7 ± 0.5 | 32.4 ± 3.2** | 27.5 ± 0.5 | 54.9 ± 1.3*** | 32.4 ± 0.7 | 56.4 ± 2.4*** | 31.8 ± 0.8 | 55.7 ± 3.5*** |
| Lung weight (mg) | 829 ± 23 | 926 ± 83 | 1121 ± 30 | 2106 ± 116*** | 1399 ± 43 | 3312 ± 338*** | 1586 ± 60 | 3751 ± 459** |
| LBI (mg g−1) | 6.29 ± 0.22 | 7.95 ± 0.70 | 4.72 ± 0.06 | 9.05 ± 0.61*** | 3.93 ± 0.10 | 9.73 ± 1.30*** | 3.54 ± 0.23 | 8.85 ± 1.01** |
| Liver weight (g) | 5.63 ± 0.35 | 5.11 ± 0.13 | 10.50 ± 0.55 | 9.43 ± 0.76 | 13.00 ± 0.83 | 16.02 ± 1.23 | 13.91 ± 1.16 | 15.97 ± 1.04 |
| LiverBI (mg g−1) | 42.4 ± 0.7 | 43.9 ± 1.2 | 44.4 ± 1.3 | 40.2 ± 2.5 | 36.4 ± 2.2 | 45.8 ± 2.8* | 30.5 ± 1.4 | 38.1 ± 2.5* |
Data are mean ± SEM; *P < 0.05, **P < 0.01, ***P < 0.001, compared to age-matched controls after 2, 6, 10 and 20 weeks of pressure overload by aortic constriction. Sham, sham-operated animals; AoB, animals subjected to aortic banding; BW, body weight; HW, heart weight; TL, tibia length; LBI, lung to body weight index; LiverBI, liver to body weight index; n = 5–8.