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. 2014 May 14;124(15):2345–2353. doi: 10.1182/blood-2014-01-552166

Table 3.

Variable associated with adherence to oral 6MP for the entire cohort and within racial subgroups

Variables Entire cohort, N = 298
Non-Hispanic whites, n = 159
Asian Americans, n = 71
African Americans, n = 68
Parameter estimate* Estimated adherence, % Parameter estimate* Estimated adherence, % Parameter estimate* Estimated adherence, % Parameter estimate* Estimated adherence, %
Intercept 5.60 4.91 3.50 5.06
Time on study
 Month 1 95.0 96.9 93.1 89.5
 Month 2 −0.208 94.0 −0.228§ 96.1 −0.53 91.7 −0.068 88.7
 Month 3 −0.427|| 92.6 −0.369|| 95.6 −1.01 89.9 −0.196 87.3
 Month 4 −0.520 92.0 −0.567|| 94.7 −0.86|| 89.0 −0.347§ 85.7
 Month 5 −0.568 91.8 −0.579|| 94.7 −1.0 88.6 −0.373|| 86.6
P for linear trend <.0001 .002 .0001 .05
Annual household income
 ≥$50 000¶ 95.3 96.7
 <$50 000 −0.86 89.7 −1.68§ 84.5
P .005 .04
Gender
 Male¶
 Female
P .15
Race
 Non-Hispanic white¶ 95.2
 Asian American −0.80 90.0
P .01
 African American −1.1 87.1
P <.0001
Paternal education
 Postgraduate degree 97.3
 Less than a postgraduate degree −0.553 95.3
P .04
Maternal education
 College degree/postgraduate/vocational training¶ 94.6
 Less than a college degree −1.46 78.9
P <.0001
Household structure
 Single parent/single child¶ 96.6 97.8 93.9
 Nuclear family −0.94 92.3 −0.69 95.7 −0.77 86.5
P .04 .04 .07
 Single parent/multiple children −0.73 93.7 −1.03§ 94.0 −0.69 85.9
P .01 .05 .18
Mother at home
 Stay-at-home mother¶ 94.9 97.2
 Working mother/absent mother −0.62§ 91.0 −1.75|| 85.6
P .02 .05

Analysis was adjusted for time from initiation of maintenance to study entry, NCI risk, blast chromosomal abnormalities and 6MP dose intensity. Age at study participation was not included in the model because of a lack of association with adherence. Test of homogeneity from month 1 through month 5: entire cohort, P < .0001; non-Hispanic white, P = .0006; Asian Americans, P = .0006; African Americans, P = .1. The individual P values for the parameter estimates for months 2 to 5 represent P values for change in adherence for each month, using month 1 as baseline.

*

More negative values of the parameter estimates indicate worse adherence rate when compared with the referent level which is indicated by ¶.

P < .001.

.01 ≤ P < .05.

§

.05 < P < .1.

||

.001 < P < .01.