Fig. 1.

Changes in prolactin (PRL) levels and tumor volume reduction (TVR) in two groups according to baseline tumor volume. Black lines indicate patients with larger tumors (larger group); gray lines, patients with smaller tumors (smaller group). The cutoff between the two groups was a baseline tumor volume of 18 cm³. Each P value between the groups was calculated at each time point with the Mann-Whitney U test. At each time point, the patients who underwent surgery before the assessment were excluded. (A) Changes in median PRL levels. (B) Changes in median TVR.