Table 1.

Demographic data and clinical and genetic characteristics of the 473 patients at recruitment (July 97/ July 98) or at the beginning of hemodialysis

Number of patients			473
Gender (M/F) - n			237/236
Age in years at the beginning of hemodialysis mean ± SD			45.8 ± 16
Time of life on HD (months)-mean ± SD			144 ± 59
BMI (Kg/m2)-mean ± SD			22.6 ± 4.7
SBP (mmHg)-mean ± SD			150 ± 19
Smoking or former smoking - n (%)			237 (50.1%)
Monthly Family income. n (%):
		< 2 MW	204 (43.4%)
		≥ 2 to 5 MW	139 (29.6%)
		> 5 MW	127 (27%)
		IGN	3 (0.6%)
Genotypes of polymorphisms:
	ACE gene- n (%):
		DD	156 (33%)
		DI	239 (50.5%)
		II	78 (16.5%)
	AGT gene-n (%):
		MM	139 (29.4%)
		MT	186 (39.3%)
		TT	148 (31.3%)
Combinations of genotypes of polymorphisms of ACE and AGT genes - n (%):
		DD + TT	46 (9.7%)
		DD + MT	62 (13.1%)
		DD + MM	48 (10.2%)
		DI + TT	79 (16.7%)
		DI + MT	91 (19.2%)
		DI + MM	69 (14.6%)
		II + TT	23 (4.9%)
		II + MT	33 (6.9%)
		II + MM	22 (4.7%)
	Comorbidities at recruiting - n (%):
		SAH (total)	386 (81.6%)
		Diabetes Mellitus (total)	70 (14.8%)
		SAH with associated diabetes	59 (12.5%)
		SAH without diabetes	327 (69%)
		Diabetes mellitus without SAH	11 (2.3%)
	Circulatory system diseases. n (%):
		Ischemic heart disease	122 (26%)
		Stroke	31(7%)

n: number of patients; M: Male gender; F: Female gender; SD: Standard-deviation; Time of life on HD: Time of life on hemodialysis from admission to hemodialysis until the event (death. conclusion of the study or kidney transplant); SBP: Systolic blood pressure; BMI: Body mass index; MW: federal minimum wage at the time of recruiting; IGN: Ignored information; ACE: Angiotensin I-converting enzyme; AGT: angiotensinogen; SAH: Systemic arterial hypertension.