Table 2. Clinical and epidemiologic features of 5 patients involved in outbreak of ANDV infection, Chile, 2011*.
Feature | Case-patient A† | Case-patient B | Case-patient C | Case-patient D | Case-patient E |
---|---|---|---|---|---|
Age, y/sex | 73/M | 31/F | 53/F | 60/F | 34/M |
Occupation | Farmer | Nursing assistant at hospital | Teacher | Cleaning personnel at hospital | Car mechanic |
Relationship to other case-patients
|
Husband of case-patient C |
Health care provider for case-patient A |
Wife of case-patient A |
Health care assistant for case-patient A |
Husband of case-patient B |
Date of symptom onset | Feb 21 | Mar 17 | Mar 18 | Mar 18 | Apr 2 |
Date of hospitalization
|
Feb 24 |
Mar 20 |
Mar 20 |
Mar 22 |
Apr 3 |
Signs and symptoms | |||||
Fever | Yes | Yes | Yes | Yes | Yes |
Respiratory symptoms‡ | Yes | Yes | No | Yes | Yes |
Gastrointestinal symptoms§ | No | No | Yes | Yes | No |
Other symptoms¶
|
No |
Yes |
Yes |
Yes |
Yes |
Mechanical ventilation, d | 28 | 8 | 0 | 1 | 6 |
Hospitalization, d | 30 | 22 | 12 | 1 | 17 |
Outcome
|
Died |
Survived |
Survived |
Died |
Survived |
Days from environmental exposure to onset of symptoms | 16 | 25–26 | 41 | 7–45 | 41–42 |
Days from exposure to hantavirus case-patient to onset of symptoms
|
NA |
19–21 |
22–25 |
18–20 |
13–27 |
Laboratory test results on admission | |||||
Platelet count, × 103/μL | 51 | 56 | 108 | 101 | 147 |
Leukocytes, × 103 cells/μL | 4,67 | 5,46 | 1,21 | 3,92 | 11,46 |
Hematocrit, % | 52 | 39 | 39 | 45 | 44 |
Lymphocytes, % | 12 | 7 | 39 | 19 | 7 |
Immunoblasts, % | Yes | Yes | Yes | NR | Yes |
IgM/IgG for ANDV | Negative# | Positive | Positive | Positive | Positive |
RT-PCR ANDV in blood cells | ND | Positive | Positive | Positive | Positive |
*ANDV, Andes virus; NA, not applicable; NR, not reported; RT-PCR, reverse transcription PCR; ND, not done. †Index case-patient. ‡Dry cough, dyspnea, cyanosis, crepitus. §Vomiting, diarrhea, nausea. ¶Severe headache, meningeal signs, myalgia, arthralgia, conjunctival infection, chills, photophobia, facial edema. #On hospital admission. Repeat testing after 24 days yielded positive results.