Table 1.

Converter sequences and stiffness per myosin head for β-cardiac/slow skeletal and fast skeletal myosin heavy chain isoforms.

Yellow, fully conserved residues, unmarked, residues where β-cardiac/slow skeletal myosin heavy chain sequence differs from the fast isoforms. Note that mutations R719W and R723G are located at positions where fast and slow isoforms differ. Mutation I736T is located at a position where fast and slow isoforms are identical. Stiffness per myosin head domain of fast and slow MyHC derived from stiffness measurements in muscle fibers and by optical trapping on myosin head domains (myosin subfragment 1) isolated from muscle tissue.