FIGURE 3.

Cellulosome assembly described with the Gene Ontology. The cellulosome is a multi-enzyme complex involved in the deconstruction of biomass for biofuel production. The central scaffoldin subunit of the cellulosome consists of a cellulose-binding module (colored green), which binds to the cellulosic substrate; and a type-II dockerin (colored dark green), which attaches the scaffoldin to the bacterial cell surface via the type-II cohesins of the anchoring protein (colored blue). The type-I cohesins (colored yellow) of the scaffoldin in turn integrate the enzyme subunits into the cellulosome via the enzyme bearing type-I dockerin module. The different subunits of the cellulosome complex and their roles are described with appropriate Gene Ontology terms, notably the “domain binding” terms that are used to curate proteins/enzymes binding to specific modules. Relevant references are in the text. Figure is based on information provided in Smith and Bayer (2013).