TABLE 3.
Adverse Experiences
| Type | <140 mm Hg (n = 4,787) | 140 to <150 mm Hg (n = 1,747) | ≥150 mm Hg (n = 1,820) | p Value |
|---|---|---|---|---|
| Alzheimer’s disease | 31 (0.6) | 11 (0.6) | 11 (0.6) | 0.98 |
| Angina | 189 (3.9) | 109 (6.2) | 80 (4.4) | 0.0004 |
| AV block | 21 (0.4) | 16 (0.9) | 13 (0.7) | 0.07 |
| CABG/PCI | 257 (5.4) | 115 (6.6) | 96 (5.3) | 0.13 |
| Cancer | 167 (3.5) | 87 (5.0) | 74 (4.1) | 0.02 |
| Constipation | 76 (1.6) | 58 (3.3) | 49 (2.7) | <0.0001 |
| Cough | 153 (3.2) | 71 (4.1) | 78 (4.3) | 0.06 |
| Dizziness | 108 (2.3) | 68 (3.9) | 80 (4.4) | <0.0001 |
| Dyspnea | 78 (1.6) | 45 (2.6) | 40 (2.2) | 0.03 |
| Gastrointestinal bleeding | 76 (1.6) | 41 (2.4) | 29 (1.6) | 0.099 |
| Gout | 33 (0.7) | 21 (1.2) | 24 (1.3) | 0.025 |
| Headache | 39 (0.8) | 33 (1.9) | 33 (1.8) | 0.0001 |
| Hyperkalemia | 4 (0.1) | 4 (0.2) | 7 (0.4) | 0.03 |
| Hypokalemia | 11 (0.2) | 5 (0.3) | 5 (0.3) | 0.90 |
| Lightheadedness | 38 (0.8) | 27 (1.5) | 30 (1.6) | 0.0027 |
| Liver enzymes out of range | 16 (0.3) | 10 (0.6) | 3 (0.2) | 0.11 |
| Parkinson’s disease | 9 (0.2) | 9 (0.5) | 4 (0.2) | 0.068 |
| Peripheral edema | 31 (0.6) | 31 (1.8) | 27 (1.5) | <0.0001 |
| Peripheral vascular disease | 90 (1.9) | 41 (2.4) | 48 (2.6) | 0.13 |
| Renal failure | 35 (0.7) | 14 (0.8) | 23 (1.3) | 0.11 |
| Symptomatic bradycardia | 83 (1.73) | 46 (2.6) | 65 (3.6) | <0.0001 |
| Unstable angina | 108 (2.3) | 62 (3.6) | 53 (2.9) | 0.013 |
| Wheezing | 28 (0.6) | 14 (0.8) | 11 (0.6) | 0.61 |
Values are n (%).
AV = atrioventricular; CABG = coronary artery bypass surgery; PCI = percutaneous coronary intervention.