Table 6. The top five genes with greatest expression differential in genes of high metastatic potential and low metastatic potential in bone and lung.
High bone metastatic cell lines are: 1833, Scp-2, Scp-25 and Scp-46. High lung metastatic cell lines are: 1834, 3481, 4142, 4173, 4175, 4180, Scp-3 and Scp-28. Low metastatic cells lines are: MDA-MB-231, Scp-6, Scp-21 and Scp-26. The gene expression values for these cell lines were used in a two-tailed t-test to calculate relative p-values. Genes with p-values over 0.06 were not included.
| Gene symbol | Bone (High/Low) | p-Value | Lung (High/Low) | p-Value |
|---|---|---|---|---|
| Top bone genes | ||||
| MMP1 | 98.28 | 0.000241 | 26.63 | 0.056189 |
| SPANX(A1/A2/B1/B2/C) | 18.23 | 0.006807 | 22.04 | 0.005703 |
| SPANXC | 14.59 | 0.003343 | 14.92 | 0.007564 |
| SPANX(B1/B2) | 12.82 | 0.017419 | 15.82 | 0.008754 |
| CXCR4 | 9.33 | 0.002383 | 0.14 | 0.052374 |
| IL11 | 8.44 | 0.001599 | 3.38 | 0.155692 |
| SRGN | 5.75 | 0.000088 | 0.99 | 0.970525 |
| Top lung genes | ||||
| SPARC | 2.01 | 0.222907 | 104.03 | 0.058864 |
| MMP1 | 98.28 | 0.000241 | 26.63 | 0.056189 |
| SPANX(A1/A2/B1/B2/C) | 18.23 | 0.006807 | 22.04 | 0.005703 |
| SPANXC | 14.59 | 0.003343 | 14.92 | 0.007564 |
| SPANX(B1/B2) | 12.82 | 0.017419 | 15.82 | 0.008754 |
| KRT81 | 3.32 | 0.101475 | 13.49 | 0.001711 |
| SOX4 | 4.67 | 0.038471 | 11.39 | 0.003905 |