Figure 1.

GÖ6976 blocks myelin inhibition in E16 rat cortical neurons. (A–D) E16 cortical neurons were cultured on PLL (A and C) or myelin (B and D) substrate for 48 h in the absence (A and B) or presence (C and D) of GÖ6976 (100 nM). The average neurite lengths from at least 200 neurons on each condition (E) and neuronal density (F) were plotted and analyzed using Student's t test and two-way ANOVA, respectively. With the same neuronal densities in four groups (F = 0.40, P = 0.76), the neurite length is significantly high in the GÖ6976-treated group than the control group on the myelin substrate (n = 3; ***P < 0.01).