Table 3.
Genotype and Adverse Event Endpoints1
| Adverse Event (Treatment Arm) | Genotype (N) | N Events (% Between Allele Groups) | Odds Ratio (95% CI) | P-value2 |
|---|---|---|---|---|
| Grade 3+ Adverse Arm A | FGFR2: rs17542768 | |||
| GA+GG (10) | 7 (20.6) | 0.086 (0.008-0.963) | 0.0194 | |
| AA (28) | 27 (79.4) | Reference | -- | |
| Grade 3+ Hematologic Arm A | FGFR2: rs2071616 | |||
| GA+AA (21) | 12 (42.9) | 0.083 (0.009-0.750) | 0.0101 | |
| GG (17) | 16 (57.1) | Reference | -- | |
| VEGFA: rs3024987 | ||||
| TC+TT (12) | 5 (17.9) | 0.093 (0.018-0.491) | 0.0023 | |
| CC (26) | 23 (82.1) | Reference | -- | |
| Grade 3+ Non-Hematologic Arm A | FGFR2: rs17542768 | |||
| GA+GG (10) | 4 (14.8) | 0.145 (0.029-0.712) | 0.0117 | |
| AA (28) | 23 (85.2) | Reference | -- | |
| Grade 3+ Non-Hematologic Arm A+B | ABCB1: rs2235015 | |||
| GT+TT (16) | 6 (18.8) | 0.185 (0.051-0.668) | 0.0074 | |
| GG (34) | 26 (81.3) | Reference | -- |
1
Only p-values < 0.02 shown
2
Fisher's Exact P-value