Table 4.
Genotype and Time to Event Endpoints1
| Time Event (Treatment Arm) | Genotype (N) | N Events (% Between Allele Groups) | Median (95% CI)2 | Hazard Ratio (95% CI)3 | P-value4 |
|---|---|---|---|---|---|
| Overall Survival Arm A | FGFR1: rs7012413 | ||||
| CT+TT (27) | 23 (85.2) | 7.5 (5.3-14.0) | 3.94 (1.35-11.51) | 0.0071 | |
| CC (11) | 4 (14.8) | 25.3 (7.1-N/A) | Reference | -- | |
| FGFR2: rs2912791 | |||||
| CT (20) | 14 (51.9) | 14.2 (6.9-25.3) | 0.66 (0.26-1.72) | 0.0002 | |
| TT (6) | 6 (22.2) | 4.5 (1.3-8.1) | 5.01 (1.54-16.28) | -- | |
| CC (11) | 7 (25.9) | 17.8 (5.1-N/A) | Reference | -- | |
| FLT4(VEGFR3): rs11748431 | |||||
| AG+AA (15) | 14 (51.9) | 7.1 (5.1-9.2) | 2.78 (1.24-6.23) | 0.0095 | |
| GG (23) | 13 (48.1) | 14.3 (6.5-N/A) | Reference | -- | |
| Progression-Free Survival Arm A | FGFR2: rs2912791 | ||||
| CT (20) | 17 (53.1) | 8.5 (4.7-14.1) | 0.55 (0.24-1.27) | 0.0010 | |
| TT (6) | 6 (18.8) | 2.2 (1.3-5.5) | 3.64 (1.17-11.26) | -- | |
| CC (10) | 9 (28.1) | 5.8 (0.7-7.1) | Reference | -- | |
| FGFR2: rs2981429 | |||||
| CT (20) | 17 (51.5) | 8.4 (4.7-14.1) | 0.27 (0.11-0.66) | 0.0106 | |
| TT (8) | 7 (21.2) | 6.1 (0.7-17.9) | 0.41 (0.15-1.16) | -- | |
| CC (9) | 9 (27.3) | 4.7 (1.3-6.3) | Reference |
1
Only p-values < 0.02 shown
2
Kaplan-Meier method
3
Cox model
4
Score P-value