Table 3.
Average Annual Age-Adjusted Incidence Ratesa for Brain and Central Nervous System Tumors by Major Histology Groupings, Histology, and Gender, CBTRUS Statistical Report: NPCR and SEER, CBTRUS Statistical Report: NPCR and SEER, 2007–2011
| Histology | Total |
Male |
Female |
||||||
|---|---|---|---|---|---|---|---|---|---|
| N | Rate | 95% CI | N | Rate | 95% CI | N | Rate | 95% CI | |
| Tumors of Neuroepithelial Tissue | 105,147 | 6.61 | (6.57–6.65) | 58,633 | 7.77 | (7.71–7.83) | 46,514 | 5.61 | (5.56–5.66) |
| Pilocytic astrocytoma | 4,954 | 0.34 | (0.33–0.35) | 2,524 | 0.34 | (0.33–0.35) | 2,430 | 0.34 | (0.32–0.35) |
| Diffuse astrocytoma | 8,629 | 0.55 | (0.54–0.57) | 4,845 | 0.65 | (0.63–0.66) | 3,784 | 0.47 | (0.46–0.49) |
| Anaplastic astrocytoma | 5,861 | 0.37 | (0.36–0.38) | 3,265 | 0.43 | (0.42–0.45) | 2,596 | 0.31 | (0.30–0.33) |
| Unique astrocytoma variants | 998 | 0.07 | (0.06–0.07) | 540 | 0.07 | (0.07–0.08) | 458 | 0.06 | (0.06–0.07) |
| Glioblastoma | 52,751 | 3.19 | (3.16–3.22) | 30,230 | 3.98 | (3.93–4.02) | 22,521 | 2.52 | (2.49–2.56) |
| Oligodendroglioma | 4,012 | 0.26 | (0.25–0.27) | 2,240 | 0.30 | (0.29–0.31) | 1,772 | 0.23 | (0.22–0.24) |
| Anaplastic oligodendroglioma | 1,650 | 0.11 | (0.10–0.11) | 910 | 0.12 | (0.11–0.13) | 740 | 0.09 | (0.09–0.10) |
| Oligoastrocytic tumors | 3,169 | 0.21 | (0.20–0.21) | 1,791 | 0.24 | (0.23–0.25) | 1,378 | 0.18 | (0.17–0.19) |
| Ependymal tumors | 6,507 | 0.42 | (0.41–0.43) | 3,646 | 0.48 | (0.46–0.49) | 2,861 | 0.36 | (0.35–0.38) |
| Glioma malignant, NOS | 7,033 | 0.46 | (0.45–0.47) | 3,518 | 0.48 | (0.47–0.50) | 3,515 | 0.45 | (0.43–0.46) |
| Choroid plexus tumors | 809 | 0.05 | (0.05–0.06) | 374 | 0.05 | (0.04–0.05) | 435 | 0.06 | (0.05–0.06) |
| Other neuroepithelial tumors | 98 | 0.01 | (0.01–0.01) | 38 | 0.01 | (0.00–0.01) | 60 | 0.01 | (0.01–0.01) |
| Neuronal and mixed neuronal-glial tumors | 4,197 | 0.28 | (0.27–0.29) | 2,201 | 0.29 | (0.28–0.30) | 1,996 | 0.26 | (0.25–0.27) |
| Tumors of the pineal region | 641 | 0.04 | (0.04–0.05) | 247 | 0.03 | (0.03–0.04) | 394 | 0.05 | (0.05–0.06) |
| Embryonal tumors | 3,838 | 0.26 | (0.25–0.27) | 2,264 | 0.31 | (0.29–0.32) | 1,574 | 0.22 | (0.21–0.23) |
| Tumors of Cranial and Spinal Nerves | 27,626 | 1.70 | (1.68–1.73) | 13,190 | 1.70 | (1.67–1.73) | 14,436 | 1.71 | (1.68–1.74) |
| Nerve sheath tumors | 27,606 | 1.70 | (1.68–1.72) | 13,180 | 1.70 | (1.67–1.73) | 14,426 | 1.71 | (1.68–1.74) |
| Other tumors of cranial and spinal nerves | 20 | 0.00 | (0.00–0.00) | – | – | – | – | – | – |
| Tumors of Meninges | 128,051 | 7.88 | (7.84–7.93) | 35,149 | 4.85 | (4.80–4.90) | 92,902 | 10.51 | (10.44–10.58) |
| Meningioma | 123,776 | 7.61 | (7.57–7.66) | 32,860 | 4.55 | (4.50–4.60) | 90,916 | 10.26 | (10.20–10.33) |
| Mesenchymal tumors | 1,285 | 0.08 | (0.08–0.09) | 632 | 0.08 | (0.08–0.09) | 653 | 0.08 | (0.07–0.09) |
| Primary melanocytic lesions | 134 | 0.01 | (0.01–0.01) | 81 | 0.01 | (0.01–0.01) | 53 | 0.01 | (0.00–0.01) |
| Other neoplasms related to the meninges | 2,856 | 0.18 | (0.17–0.19) | 1,576 | 0.21 | (0.20–0.22) | 1,280 | 0.16 | (0.15–0.17) |
| Lymphomas and Hematopoietic Neoplasms | 7,339 | 0.46 | (0.45–0.47) | 3,858 | 0.52 | (0.50–0.54) | 3,481 | 0.40 | (0.39–0.41) |
| Lymphoma | 7,125 | 0.44 | (0.43–0.45) | 3,745 | 0.51 | (0.49–0.52) | 3,380 | 0.39 | (0.37–0.40) |
| Other hematopoietic neoplasms | 214 | 0.01 | (0.01–0.02) | 113 | 0.01 | (0.01–0.02) | 101 | 0.01 | (0.01–0.01) |
| Germ Cell Tumors and Cysts | 1,502 | 0.10 | (0.10–0.11) | 1,018 | 0.14 | (0.13–0.14) | 484 | 0.07 | (0.06–0.07) |
| Germ cell tumors, cysts and heterotopias | 1,502 | 0.10 | (0.10–0.11) | 1,018 | 0.14 | (0.13–0.14) | 484 | 0.07 | (0.06–0.07) |
| Tumors of Sellar Region | 54,546 | 3.47 | (3.44–3.50) | 24,658 | 3.25 | (3.21–3.30) | 29,888 | 3.76 | (3.72–3.81) |
| Tumors of the pituitary | 51,700 | 3.29 | (3.26–3.32) | 23,312 | 3.08 | (3.04–3.12) | 28,388 | 3.57 | (3.53–3.61) |
| Craniopharyngioma | 2,846 | 0.18 | (0.18–0.19) | 1,346 | 0.18 | (0.17–0.19) | 1,500 | 0.19 | (0.18–0.20) |
| Unclassified Tumors | 18,964 | 1.19 | (1.17–1.21) | 8,457 | 1.19 | (1.16–1.21) | 10,507 | 1.20 | (1.18–1.22) |
| Hemangioma | 4,723 | 0.30 | (0.29–0.31) | 2,051 | 0.27 | (0.26–0.28) | 2,672 | 0.33 | (0.32–0.34) |
| Neoplasm, unspecified | 14,160 | 0.88 | (0.87–0.90) | 6,369 | 0.91 | (0.89–0.93) | 7,791 | 0.87 | (0.85–0.88) |
| All other | 81 | 0.00 | (0.00–0.01) | 37 | 0.01 | (0.00–0.01) | 44 | 0.01 | (0.00–0.01) |
| TOTALb | 343,175 | 21.42 | (21.35–21.49) | 144,963 | 19.42 | (19.32–19.52) | 198,212 | 23.26 | (23.15–23.36) |
aRates are per 100,000 and are age-adjusted to the 2000 US standard population.
bRefers to all brain tumors including histologies not presented in this table.
– Counts are not presented when fewer than 16 cases were reported for the specific histology category. Suppressed cases are included in the total count.
Abbreviations: CBTRUS, Central Brain Tumor Registry of the United States; NPCR, National Program of Cancer Registries; SEER, Surveillance, Epidemiology and End Results program; CI, confidence interval; NOS, not otherwise specified.