Table 2.
Risk of Schizophrenia Associated With Site of First Infection in a Cohort of 843 390 Persons Born Between 1981 and 1996 of Whom 3409 Developed Schizophrenia During 9.7 Million Person Years of Follow-up
| Site of Infection | Cases | Incidence Rate Ratios (95% CI) | |
|---|---|---|---|
| Basic modela | Fully adjusted modelb | ||
| Sepsis | 26 | 2.26 (1.49–3.25) | 2.08 (1.38–3.00) |
| Hepatitis | 5 | 4.05 (1.45–8.71) | 3.43 (1.23–7.39) |
| Intestinal | 195 | 1.44 (1.24–1.67) | 1.34 (1.15–1.55) |
| Skin | 141 | 1.47 (1.23–1.73) | 1.38 (1.16–1.63) |
| Respiratory | 502 | 1.52 (1.38–1.68) | 1.41 (1.27–1.55) |
| Urologic | 79 | 2.26 (1.79–2.81) | 2.08 (1.65–2.59) |
| Genital | 28 | 3.88 (2.60–5.54) | 3.47 (2.33–4.96) |
| Central nervous system | 17 | 1.01 (0.60–1.57) | 0.98 (0.58–1.52) |
| Ottis media | 165 | 1.34 (1.14–1.57) | 1.23 (1.05–1.44) |
| Other types | 391 | 1.48 (1.32–1.64) | 1.39 (1.25–1.55) |
| No infections | 1860 | 1.00 (reference) | 1.00 (reference) |
Note: aAdjusted for calendar year, sex, and its interaction with age.
bFurther adjustment for parental history of mental illness.