Fig. 1.

Example of a nuclear family from the COGS-1 database that was extended using FIGS information. A dashed box indicates members of the nuclear family, all of whom directly participated in the study. The age of each participating subject is indicated in the upper righthand corner and subject IDs are given, along with an indication of whether DNA was collected and whether DIGS, FIGS, or endophenotypes are available for the subject. DIGS-based diagnoses are indicated for each participating member, and FIGS-based diagnoses are indicated for additional first-degree relatives of a participating member with additional diagnostic information below as relevant. Squares indicate males and circles indicate females, and diagonal lines indicate the subject is deceased. COGS-1, Consortium on the Genetics of Schizophrenia; DIGS, Diagnostic Interview for Genetic Studies; ETOH, alcohol dependence; FIGS, Family Interview for Genetic Studies; MDD, major depressive disorder; no Dx, never mentally ill; SZ, schizophrenia.