Table 2.
X | Y | Z | Hemisphere | Anatomical Landmark | Mean T Value | P Value, 2 Tail | Cluster size (mm3) | Seed × Dx F Test (F/P Value) | Overlap |
---|---|---|---|---|---|---|---|---|---|
MD thalamic seed SCZ < HCS | |||||||||
0 | −59 | −35 | Midline | Cerebellum | −3.16 | .002 | 100575 | 5.36/.022* | Y |
−18 | −100 | −18 | Left | Lingual gyrus (BA 18) | −2.76 | .006 | 918 | n.s. | Y |
1 | −99 | −15 | Midline | Lingual gyrus (BA 18) | −2.70 | .008 | 1080 | 7.67/.0061** | Y |
−10 | −15 | 3 | Left | Mediodorsal thalamus | −3.25 | .001 | 9315 | 22.8/<.001*** | Y |
0 | 26 | 35 | Midline | Cingulate gyrus (BA 32) | −3.07 | .002 | 47682 | 12.4/<.001*** | Y |
21 | 6 | 1 | Right | Putamen | −2.80 | .006 | 1188 | n.s. | Y |
−24 | 19 | 21 | Left | Caudate | −2.80 | .006 | 270 | 3.98/.048* | N |
−10 | −32 | 19 | Left | Posterior cingulate | −2.93 | .004 | 378 | 3.18/.077trend | N |
6 | −17 | 31 | Right | Cingulate gyrus (BA 23) | −2.85 | .005 | 2889 | n.s. | Y |
8 | 58 | 35 | Right | Superior frontal gyrus (BA 9) | −2.67 | .008 | 378 | n.s. | Y |
MD thalamic seed SCZ > HCS | |||||||||
7 | −73 | 14 | Right | Occipital cortex (BA 18) | 3.12 | .002 | 26136 | 7.22/.008** | Y |
1 | −23 | 29 | Midline | Cingulate gyrus (BA 23) | 3.35 | .001 | 120852 | 44.4/<.001*** | Y |
−41 | −68 | 5 | Left | Middle occipital gyrus | 2.76 | .006 | 2457 | 7.67/.0062** | Y |
−50 | −66 | 3 | Left | Middle temporal gyrus (BA 37) | 2.55 | .012 | 270 | n.s. | Y |
49 | −65 | 11 | Right | Middle temporal gyrus (BA 39) | 2.49 | .014 | 432 | n.s. | Y |
−24 | −68 | 19 | Left | Precuneus (BA 31) | 2.71 | .007 | 405 | n.s. | Y |
LGN thalamic seed SCZ < HCS | |||||||||
0 | −64 | −38 | Midline | Cerebellum | −3.17 | .002 | 79866 | n.s. | Y |
2 | −23 | −15 | Midline | Brainstem | −2.63 | .009 | 621 | n.s. | Y |
3 | −8 | 2 | Midline | Mediodorsal thalamus | −3.02 | 003 | 9018 | n.s. | Y |
36 | 33 | 35 | Right | Middle frontal gyrus (BA 9) | −3.18 | .002 | 13878 | n.s. | Y |
−38 | 36 | 33 | Left | Middle frontal gyrus (BA 9) | −3.38 | .001 | 7884 | n.s. | Y |
2 | −13 | 27 | Midline | Cingulate gyrus (BA 23) | −2.92 | .004 | 14013 | 8.04/.005** | Y |
1 | 20 | 42 | Midline | Cingulate gyrus (BA 32) | −2.95 | .004 | 10800 | n.s. | Y |
4 | 58 | 33 | Midline | Superior frontal gyrus (BA 9) | −2.92 | .004 | 432 | n.s. | Y |
LGN thalamic seed SCZ > HCS | |||||||||
22 | −44 | 18 | Right | Posterior parahippocampal gyrus | 3.01 | .003 | 53379 | n.s. | N |
−1 | 24 | −4 | Midline | Anterior cingulate (BA 24/32) | 2.94 | .004 | 8424 | 8.89/.0033** | N |
−37 | −78 | −12 | Left | Fusiform gyrus (BA 19) | 2.66 | .009 | 432 | n.s. | N |
−53 | −27 | 4 | Left | Superior temporal gyrus (BA 22) | 2.97 | .003 | 7344 | n.s. | Y |
46 | −3 | −6 | Right | Insular cortex (BA 13) | 2.67 | .008 | 486 | n.s. | Y |
−38 | −38 | 10 | Left | Superior temporal gyrus (BA 41) | 2.80 | .006 | 1890 | 6.83/.0098** | Y |
−42 | −72 | 0 | Left | Middle occipital gyrus (BA 19) | 2.59 | .010 | 621 | n.s. | Y |
−45 | −16 | 40 | Left | Post-central gyrus (BA 3) | 3.09 | .002 | 19251 | n.s. | Y |
12 | −16 | 74 | Right | Motor cortex | 2.75 | .007 | 891 | n.s. | Y |
Note: SCZ, schizophrenia patients; HCS, healthy comparison subjects; BA, Brodmann area. All statistics were calculated across all voxels for the identified cluster that survived the group t test presented in figure 1. Seed × Dx F test denotes an interaction between LGN vs MD seed and SCZ vs HCS groups; Dx, Diagnosis.
*Negative T value denotes a reduction for SCZ vs HCS.