Table 2.

MD and LGN Results—SCZ Analysis

X	Y	Z	Hemisphere	Anatomical Landmark	Mean T Value	P Value, 2 Tail	Cluster size (mm3)	Seed × Dx F Test (F/P Value)	Overlap
MD thalamic seed SCZ < HCS
0	−59	−35	Midline	Cerebellum	−3.16	.002	100575	5.36/.022*	Y
−18	−100	−18	Left	Lingual gyrus (BA 18)	−2.76	.006	918	n.s.	Y
1	−99	−15	Midline	Lingual gyrus (BA 18)	−2.70	.008	1080	7.67/.0061**	Y
−10	−15	3	Left	Mediodorsal thalamus	−3.25	.001	9315	22.8/<.001***	Y
0	26	35	Midline	Cingulate gyrus (BA 32)	−3.07	.002	47682	12.4/<.001***	Y
21	6	1	Right	Putamen	−2.80	.006	1188	n.s.	Y
−24	19	21	Left	Caudate	−2.80	.006	270	3.98/.048*	N
−10	−32	19	Left	Posterior cingulate	−2.93	.004	378	3.18/.077trend	N
6	−17	31	Right	Cingulate gyrus (BA 23)	−2.85	.005	2889	n.s.	Y
8	58	35	Right	Superior frontal gyrus (BA 9)	−2.67	.008	378	n.s.	Y
MD thalamic seed SCZ > HCS
7	−73	14	Right	Occipital cortex (BA 18)	3.12	.002	26136	7.22/.008**	Y
1	−23	29	Midline	Cingulate gyrus (BA 23)	3.35	.001	120852	44.4/<.001***	Y
−41	−68	5	Left	Middle occipital gyrus	2.76	.006	2457	7.67/.0062**	Y
−50	−66	3	Left	Middle temporal gyrus (BA 37)	2.55	.012	270	n.s.	Y
49	−65	11	Right	Middle temporal gyrus (BA 39)	2.49	.014	432	n.s.	Y
−24	−68	19	Left	Precuneus (BA 31)	2.71	.007	405	n.s.	Y
LGN thalamic seed SCZ < HCS
0	−64	−38	Midline	Cerebellum	−3.17	.002	79866	n.s.	Y
2	−23	−15	Midline	Brainstem	−2.63	.009	621	n.s.	Y
3	−8	2	Midline	Mediodorsal thalamus	−3.02	003	9018	n.s.	Y
36	33	35	Right	Middle frontal gyrus (BA 9)	−3.18	.002	13878	n.s.	Y
−38	36	33	Left	Middle frontal gyrus (BA 9)	−3.38	.001	7884	n.s.	Y
2	−13	27	Midline	Cingulate gyrus (BA 23)	−2.92	.004	14013	8.04/.005**	Y
1	20	42	Midline	Cingulate gyrus (BA 32)	−2.95	.004	10800	n.s.	Y
4	58	33	Midline	Superior frontal gyrus (BA 9)	−2.92	.004	432	n.s.	Y
LGN thalamic seed SCZ > HCS
22	−44	18	Right	Posterior parahippocampal gyrus	3.01	.003	53379	n.s.	N
−1	24	−4	Midline	Anterior cingulate (BA 24/32)	2.94	.004	8424	8.89/.0033**	N
−37	−78	−12	Left	Fusiform gyrus (BA 19)	2.66	.009	432	n.s.	N
−53	−27	4	Left	Superior temporal gyrus (BA 22)	2.97	.003	7344	n.s.	Y
46	−3	−6	Right	Insular cortex (BA 13)	2.67	.008	486	n.s.	Y
−38	−38	10	Left	Superior temporal gyrus (BA 41)	2.80	.006	1890	6.83/.0098**	Y
−42	−72	0	Left	Middle occipital gyrus (BA 19)	2.59	.010	621	n.s.	Y
−45	−16	40	Left	Post-central gyrus (BA 3)	3.09	.002	19251	n.s.	Y
12	−16	74	Right	Motor cortex	2.75	.007	891	n.s.	Y

Note: SCZ, schizophrenia patients; HCS, healthy comparison subjects; BA, Brodmann area. All statistics were calculated across all voxels for the identified cluster that survived the group t test presented in figure 1. Seed × Dx F test denotes an interaction between LGN vs MD seed and SCZ vs HCS groups; Dx, Diagnosis.

*Negative T value denotes a reduction for SCZ vs HCS.