Table 3.
X | Y | Z | Hemisphere | Anatomical Landmark | Mean T Value | P Value 2 Tail | Cluster Size (mm3) | Seed × Dx F Test (F/P Value) | Overlap | ||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
BPP vs HCS | BPW vs HCS | BPP vs BPW | BPP vs HCS | BPW vs HCS | BPP vs BPW | ||||||||
MD thalamic seed F test results | |||||||||||||
53 | −15 | 9 | Right | Superior temporal gyrus (BA 22) | 2.79 | 1.99 | 0.96 | .006 | .049 | .340 | 19386 | 3.62/.06trend | Y |
−52 | −18 | 10 | Left | Superior temporal gyrus (BA 41) | 2.84 | 2.01 | 0.95 | .006 | .047 | .345 | 11367 | 2.78/.1trend | N |
−35 | −9 | 3 | Left | Insular cortex (BA 13) | 2.99 | 2.66 | 0.54 | .004 | .009 | .591 | 1134 | n.s. | N |
−30 | 10 | 7 | Left | Anterior insular cortex (BA 13) | 1.84 | 3.13 | 1.11 | .069 | .002 | .271 | 459 | n.s. | N |
−45 | 5 | 6 | Left | Insular cortex (BA 13) | 1.07 | 3.03 | 1.84 | .288 | .003 | .070 | 864 | 2.84/.1trend | N |
40 | −8 | 7 | Right | Insular cortex (BA 13) | 1.67 | 2.95 | 0.79 | .099 | .004 | .432 | 1053 | n.s. | N |
0 | −52 | 35 | Midline | Precuneus (BA 7) | −2.80 | −2.30 | 0.54 | .006 | .024 | .591 | 11232 | n.s. | N |
44 | −16 | 56 | Right | Precentral gytus (BA 4) | 2.77 | 2.33 | 0.64 | .007 | .022 | .524 | 594 | n.s. | N |
LGN thalamic seed F test results | |||||||||||||
14 | −15 | 0 | Right | Thalamus | −2.44 | −2.21 | 0.28 | .017 | .030 | .780 | 5913 | n.s. | N |
3 | 37 | 15 | Midline | Anterior cingulate (BA 32) | −2.17 | −3.22 | 0.79 | .033 | .002 | .432 | 11070 | n.s. | N |
58 | −8 | 0 | Right | Superior temporal gyrus (BA 22) | 2.70 | 1.29 | 1.40 | .008 | .200 | .166 | 1485 | n.s. | Y |
52 | −33 | 14 | Right | Superior temporal gyrus (BA 41) | 2.35 | 2.67 | 0.12 | .021 | .009 | .905 | 4050 | n.s. | Y |
45 | −10 | 26 | Right | Precentral gyrus (BA 6) | 2.68 | 2.16 | 0.47 | .009 | .033 | .640 | 1107 | n.s. | Y |
Note: BPP, bipolar patients with psychosis history; BPW, bipolar patients without psychosis history; HCS, healthy control subjects; BA, Brodmann area. All statistics were calculated across all voxels for the identified cluster that survived the 1-way ANOVA F test presented in figures 3 and 4. Values marked in bold font denote the specific pairwise effect that is driving the 1-way ANOVA result. Seed × Dx F test denotes an interaction between LGN vs MD seed and BPW vs BPP groups; Dx, Diagnosis.
*Negative T value denotes a reduction for BPW or BPP vs HCS.