Table 3.

MD and LGN Results—Bipolar Analyses

X	Y	Z	Hemisphere	Anatomical Landmark	Mean T Value			P Value 2 Tail			Cluster Size (mm3)	Seed × Dx F Test (F/P Value)	Overlap
					BPP vs HCS	BPW vs HCS	BPP vs BPW	BPP vs HCS	BPW vs HCS	BPP vs BPW
MD thalamic seed F test results
53	−15	9	Right	Superior temporal gyrus (BA 22)	2.79	1.99	0.96	.006	.049	.340	19386	3.62/.06trend	Y
−52	−18	10	Left	Superior temporal gyrus (BA 41)	2.84	2.01	0.95	.006	.047	.345	11367	2.78/.1trend	N
−35	−9	3	Left	Insular cortex (BA 13)	2.99	2.66	0.54	.004	.009	.591	1134	n.s.	N
−30	10	7	Left	Anterior insular cortex (BA 13)	1.84	3.13	1.11	.069	.002	.271	459	n.s.	N
−45	5	6	Left	Insular cortex (BA 13)	1.07	3.03	1.84	.288	.003	.070	864	2.84/.1trend	N
40	−8	7	Right	Insular cortex (BA 13)	1.67	2.95	0.79	.099	.004	.432	1053	n.s.	N
0	−52	35	Midline	Precuneus (BA 7)	−2.80	−2.30	0.54	.006	.024	.591	11232	n.s.	N
44	−16	56	Right	Precentral gytus (BA 4)	2.77	2.33	0.64	.007	.022	.524	594	n.s.	N
LGN thalamic seed F test results
14	−15	0	Right	Thalamus	−2.44	−2.21	0.28	.017	.030	.780	5913	n.s.	N
3	37	15	Midline	Anterior cingulate (BA 32)	−2.17	−3.22	0.79	.033	.002	.432	11070	n.s.	N
58	−8	0	Right	Superior temporal gyrus (BA 22)	2.70	1.29	1.40	.008	.200	.166	1485	n.s.	Y
52	−33	14	Right	Superior temporal gyrus (BA 41)	2.35	2.67	0.12	.021	.009	.905	4050	n.s.	Y
45	−10	26	Right	Precentral gyrus (BA 6)	2.68	2.16	0.47	.009	.033	.640	1107	n.s.	Y

Note: BPP, bipolar patients with psychosis history; BPW, bipolar patients without psychosis history; HCS, healthy control subjects; BA, Brodmann area. All statistics were calculated across all voxels for the identified cluster that survived the 1-way ANOVA F test presented in figures 3 and 4. Values marked in bold font denote the specific pairwise effect that is driving the 1-way ANOVA result. Seed × Dx F test denotes an interaction between LGN vs MD seed and BPW vs BPP groups; Dx, Diagnosis.

*Negative T value denotes a reduction for BPW or BPP vs HCS.