Table 5.

MD and LGN Results—Bipolar vs Schizophrenia Analyses

X	Y	Z	Hemisphere	Anatomical Landmark	Mean T Value		P Value 2 Tail		Cluster size (mm3)
					BPP vs SCZ	BPW vs SCZ	BPP vs SCZ	BPW vs SCZ
MD thalamic seed SCZ vs BPW
57	−27	9	Right	Superior temporal gyrus (BA 42)	—	2.86	—	.005	14769
−40	−27	−4	Left	Temporal lobe (BA 22)	—	2.54	—	.012	891
41	−30	−6	Right	Temporal lobe	—	2.66	—	.009	405
−51	−37	8	Left	Middle temporal gyrus	—	2.93	—	.004	7209
−58	−9	18	Left	Postcentral gyrus (BA 43)	—	2.91	—	.004	3240
39	−27	11	Right	Superior temporal gyrus (BA 13)	—	2.67	—	.009	648
−33	−61	−43	Left	Cerebellum	—	−2.81	—	.006	7749
30	−66	−44	Right	Cerebellum	—	−2.94	—	.004	6561
0	−76	−38	Midline	Cerebellum	—	−2.74	—	.007	6453
MD thalamic seed SCZ vs BPP
−25	−66	−37	Left	Cerebellum	−2.72	-	.008	-	6831
LGN thalamic seed SCZ vs BPW
1	−66	−45	Midline	Cerebellum	—	−2.97	—	.004	30834
−31	11	8	Left	Insula (BA 13)	—	−2.92	—	.004	7128
−1	0	53	Midline	Medial frontal gyrus (BA 6)	—	−2.87	—	.005	8397
−30	−7	51	Left	Middle frontal gyrus (BA 6)	—	−2.85	—	.005	3078
LGN thalamic seed SCZ vs BPP
−12	44	41	Left	Superior frontal gyrus (BA 8)	−2.56	—	.012	—	270
−11	27	50	Left	Superior frontal gyrus (BA 6)	−2.83	—	.006	—	1620
−13	2	55	Left	Medial frontal gyrus (BA 6)	−2.83	—	.006	—	4509

Note: BPP, bipolar patients with psychosis history; BPW, bipolar patients without psychosis history; SCZ, schizophrenia patients; BA, Brodmann area. All statistics were calculated across all voxels for the identified cluster that survived the group pairwise comparisons presented in figure 5.

*Negative T value denotes a reduction for SCZ vs BPW or BPP.