Figure 8. Minocycline inhibits prorenin induced pro-inflammatory cytokine production in microglial cells.

Mouse N-9 (A) and SD rat primary microglial cells (B) were treated with control solution (DMEM) or prorenin (20 nmol/L) in the presence or absence of minocycline (1 µmol/L) for 24 hr; cell lysates were analyzed for IL-1β and TNFα mRNAs. Data are means ± SEM from 6 experiments. * P<0.05 vs. control.