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. 2014 Oct 10;9(10):e109432. doi: 10.1371/journal.pone.0109432

Figure 1. Increased contribution of SK3 and IK1 channels to the ACh-induced relaxation in coronary arteries from OZR.

Figure 1

(A, B) Isometric tension recordings showing the effects of increasing concentrations of acetylcholine (ACh) on coronary arteries precontracted with 5-HT (1–3 µM) and effect of treatment with the SK3 channel inhibitor apamin (0.5 µM) plus the IK1 channel inhibitor TRAM34 (0.4 µM) in LZR (A) and OZR (B). (C–D) Effects of apamin, TRAM34, apamin plus TRAM34 and L-NOARG (100 µM) on the average concentration-dependent curves for the relaxation to ACh in coronary arteries from LZR (C) and OZR (D). Results are expressed as a percentage of the contraction induced by 5-HT. Points represent mean ± SEM of n = 6–9 arteries (1–2 arteries per animal).