. 2014 Oct 10;9(10):e109432. doi: 10.1371/journal.pone.0109432

Table 1. Effect of selective inhibitors of NOS (L-NOARG), SK3 (apamin) and IK1 channels (TRAM 34), and combined inhibition of SK3/IK1 channels (A+T) on the ACh and SNAP-induced vasodilation in coronary arteries from LZR and OZR.

ACh
		LZR				OZR
	pEC₅₀	E_max	ΔBT	n	pEC₅₀	E_max	ΔBT	n
control	7.01±0.19	91±3	-	7	6.9±0.15	90±5	-	6
L-NOARG	-	2±8^c	25±14	7	-	22±6^c	31±13	6
control	6.8±0.16	87±6	-	7	6.8±0.13	93±2	-	8
apamin	7.0±0.18^a	73±5^a	9±3	7	6.42±0.10^a	80±4^b	14±5	8
control	7.0±0.2	90±2	-	6	6.9±0.19	86±3	-	9
TRAM34	6.9±0.13	73±6^a	9±6	6	6.43±0.16^a	65±5^c	25±6^†	9
control	6.9±0.22	89±6	-	9	6.9±0.25	90±4	-	6
A+T	6.8±0.19	74±3^b	10±2	9	6.1±0.14^b	68±1^c	35±8^#	6

Values represent mean ± S.E.M. of the number n of individual arteries. pEC₅₀ is –logEC₅₀. E_max is maximal relaxation expressed as percentage of 5-HT-induced precontraction. ΔBT; is the increase in basal tension expressed as percentage of KPSS-induced contraction. Significant differences from controls were analyzed using paired t test; ^a P <0.05; ^b P <0.01; ^c P <0.001 vs control; or one way ANOVA followed by a Bonferroni test for across-group comparisons; ^# P <0.05 vs A+T-treated LZR; ^† P <0.05 vs TRAM34-treated LZR.