Table 2. Nominally significant associations for NSCL/P with SNPs in and around BMP4 jointly considering G and interaction with ETS using conditional logistic regression models in 786 complete Asian trios with data on ETS.
| SNP name | Position | All Trios informative for ETS | Trios without exposure to ETS | ||||
| MAF (%) | OR (95%CI) _GxE | P_2df LRT (G+GxETS) | MAF (%) | OR (95%CI) | P | ||
| rs7152946 | 54051076 | 11.9 | 1.82 (1.18, 2.83) | 7.48*10−3 | 10.8 | 0.65 (0.49, 0.87) | 3.41*10−3 |
| rs7156227 | 54055337 | 20.9 | 1.55 (1.08, 2.23) | 1.78*10−4 | 20.0 | 0.61 (0.49, 0.78) | 4.52*10−5 |
| rs1380131 | 54072858 | 9.4 | 0.91 (0.54, 1.54) | 1.98*10−2 | 10.1 | 0.73 (0.53, 0.99) | 4.32*10−2 |
| rs10483623 | 54090077 | 7.0 | 0.78 (0.44, 1.37) | 8.88*10−2 | 6.8 | 1.46 (1.03, 2.08) | 3.50*10−2 |
| rs17126895 | 54248083 | 41.0 | 0.83 (0.62, 1.12) | 1.32*10−1 | 41.0 | 1.21 (1.01, 1.45) | 4.46*10−2 |
| rs8017615 | 54259598 | 9.5 | 0.62 (0.37, 1.03) | 7.69*10−2 | 9.8 | 1.39 (1.03, 1.88) | 3.36*10−2 |
| rs10498466 | 54391813 | 48.0 | 0.89 (0.66, 1.19) | 4.16*10−2 | 47.7 | 1.24 (1.04, 1.49) | 1.76*10−2 |
| rs1957860 | 54429355 | 11.7 | 1.42 (0.90, 2.26) | 6.37*10−2 | 11.7 | 0.72 (0.54, 0.95) | 1.99*10−2 |
| rs8014363 | 54431575 | 11.3 | 1.51 (0.94, 2.41) | 6.86*10−2 | 11.4 | 0.71 (0.53, 0.96) | 2.33*10−2 |