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. 2014 Oct 10;9(10):e109763. doi: 10.1371/journal.pone.0109763

Figure 8. MMP12KO mice are partially protected from heart and skin fibrosis in the Ang II model.

Figure 8

Picrosirius Red and Gomori's Trichrome staining was performed on paraffin sections respectively from the heart (A) and skin (B) of WT and MMP12KO mice infused with PBS or Ang II. Representative photographs are shown from five animals per group. C. Perivascular and interstitial collagen content in the heart was quantified using ImageJ software by measuring the ratio of the red area to the total area of the heart. D. Total hydroxyproline content in PBS- and Ang II-treated WT and MMP12KO mice. Values are the mean±SD of 6 mice in each group; *p≤0.05; **p≤0.01.