Table 3. Association of CXCL17 with clinicopathological characteristics.
Nontumoral CXCL17 | Peritumoral CXCL17 | Intratumoral CXCL17 | ||||||||
Variable | Low | High | P | Low | High | P | Low | High | P | |
Age (year) | ≤51 | 58 | 58 | 0.946 | 62 | 54 | 0.320 | 60 | 56 | 0.549 |
>51 | 56 | 55 | 52 | 59 | 53 | 58 | ||||
Gender | Male | 99 | 98 | 0.979 | 100 | 97 | 0.676 | 98 | 99 | 0.979 |
Female | 15 | 15 | 14 | 16 | 15 | 15 | ||||
HBsAg | Negtive | 8 | 10 | 0.610 | 9 | 9 | 0.984 | 9 | 9 | 0.984 |
Positive | 106 | 103 | 105 | 104 | 104 | 105 | ||||
Cirrhosis | Absent | 47 | 38 | 0.237 | 50 | 35 | 0.045 | 49 | 36 | 0.067 |
Present | 67 | 75 | 64 | 78 | 64 | 78 | ||||
ALT (U/liter) | ≤42 | 67 | 71 | 0.531 | 68 | 70 | 0.723 | 70 | 68 | 0.723 |
>42 | 47 | 42 | 46 | 43 | 43 | 46 | ||||
AST (U/liter) | ≤42 | 62 | 69 | 0.309 | 60 | 71 | 0.120 | 64 | 67 | 0.745 |
>42 | 52 | 44 | 54 | 42 | 49 | 47 | ||||
AFP (ng/ml) | ≤25 | 38 | 40 | 0.743 | 35 | 43 | 0.244 | 33 | 45 | 0.103 |
>25 | 76 | 73 | 79 | 70 | 80 | 69 | ||||
Tumor size (cm) | ≤5 | 51 | 45 | 0.454 | 48 | 48 | 0.955 | 49 | 47 | 0.745 |
>5 | 63 | 68 | 66 | 65 | 64 | 67 | ||||
Tumor differentiation | I + II | 58 | 71 | 0.069 | 54 | 75 | 0.004 | 63 | 66 | 0.745 |
III + IV | 56 | 42 | 60 | 38 | 50 | 48 | ||||
Vascular invasion | Absent | 93 | 93 | 0.888 | 95 | 91 | 0.583 | 95 | 91 | 0.406 |
Present | 21 | 20 | 19 | 22 | 18 | 23 | ||||
Tumor multiplicity | Solitary | 83 | 87 | 0.467 | 83 | 87 | 0.467 | 84 | 86 | 0.848 |
Multiple | 31 | 26 | 31 | 26 | 29 | 28 | ||||
Capsulation | Absent | 23 | 29 | 0.325 | 21 | 31 | 0.106 | 23 | 29 | 0.362 |
Present | 91 | 84 | 93 | 82 | 90 | 85 | ||||
TNM stage | I + II | 67 | 55 | 0.127 | 68 | 54 | 0.073 | 66 | 56 | 0.161 |
III + IV | 47 | 58 | 46 | 59 | 47 | 58 | ||||
BCLC stage | 0–A | 68 | 68 | 0.935 | 69 | 67 | 0.850 | 69 | 67 | 0.725 |
B–C | 46 | 45 | 45 | 46 | 44 | 47 |
Note: Underlined terms indicate statistical significance. Abbreviations: AFP: alpha-fetoprotein; ALT: alanine aminotransferase; AST: aspartate aminotransferase; BCLC: Barcelona Clinic Liver Cancer; CI: confidence interval; HBsAg: hepatitis B surface antigen; TNM: tumor-nodes-metastasis.