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. Author manuscript; available in PMC: 2015 Apr 1.
Published in final edited form as: Gene Ther. 2014 Jul 3;21(10):855–865. doi: 10.1038/gt.2014.57

Figure 4. Mouse retinal transduction after subretinal administration of LV vectors.

Figure 4

LV vectors containing the CMV-EGFP expression cassette were injected subretinally in adult C57BL/6 mice, and retinas were analyzed 2 weeks post injection. The dose used was the maximum possible for each LV vector based on the prep titers. The n of retinas, the dose of each vector and the relative transduction observed in photoreceptors and retinal pigment epithelium are indicated below each panel. RPE was the only target of most LV pseudotypes but LV-GP64, which transduced some photoreceptors (see inset). Abbreviations: rpe: retinal pigment epithelium; onl: outer nuclear layer; inl: inner nuclear layer; gcl: ganglion cell layer; PR: photoreceptors; TU: transducing units; NT: not transduced. Magnification=20×; scale bar=50μm.